PMID- 9342964
OWN - NLM
STAT- MEDLINE
DCOM- 19971118
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 48
IP  - 10
DP  - 1997 Oct
TI  - Comparison of multiple-dose and once-daily nitrate therapy in 1212 patients with 
      stable angina pectoris: effects on quality of life indices. Dutch Mononitrate 
      Quality of Life (DUMQOL) Study Group.
PG  - 855-62
AB  - BACKGROUND: Nitrates, although important for the management of anginal symptoms, 
      produce significant side effects. Little is known about their net effects on 
      health-related, quality-of-life indices. METHODS: In a self-controlled, 6-month 
      study, the effects on symptoms and quality of life of multiple-dose and 
      once-daily nitrate therapy were evaluated in 1212 patients with stable angina 
      pectoris. Quality of life was assessed by a test battery based on the 
      exercise-tolerance index of Wiklund, the psychological well-being index of Dupuy, 
      and the Short Form 36 questionnaire of Stewart. The internal consistency and 
      reliability of the multi-item scales were estimated by Cronbach's alpha 
      coefficients. RESULTS: The effects of the two treatment regimens on pain index 
      and number of additional sublingual nitrate tablets required were not different. 
      However, based on the New York Heart Association (NYHA) angina classification, 
      patients improved better on the once-daily than on the multiple-dose regimen: by 
      > 1 category in 281 vs 62 of the patients (P < 0.0001); mobility and 
      psychological distress indices also improved (P = 0.006, and P = 0.007). 
      CONCLUSIONS: Once-daily nitrate therapy not only provides a better NYHA angina 
      classification than multiple-dose therapy does, but also provides a better 
      quality of life as estimated by improvement of mobility and distress indices, the 
      most important indicators of quality of life in this category of patients.
FAU - Niemeyer, M G
AU  - Niemeyer MG
AD  - Martini Hospital, Groningen, The Netherlands.
FAU - Kleinjans, H A
AU  - Kleinjans HA
FAU - de Ree, R
AU  - de Ree R
FAU - Zwinderman, A H
AU  - Zwinderman AH
FAU - Cleophas, T J
AU  - Cleophas TJ
FAU - van der Wall, E E
AU  - van der Wall EE
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Tablets)
RN  - 0 (Vasodilator Agents)
RN  - IA7306519N (Isosorbide Dinitrate)
RN  - LX1OH63030 (isosorbide-5-mononitrate)
SB  - IM
MH  - Activities of Daily Living
MH  - Administration, Sublingual
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina Pectoris/*drug therapy/physiopathology/psychology
MH  - Calcium Channel Blockers/therapeutic use
MH  - Drug Administration Schedule
MH  - Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Isosorbide Dinitrate/administration & dosage/adverse effects/*analogs & 
      derivatives/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Patient Compliance
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Stress, Psychological/physiopathology
MH  - Tablets
MH  - Vasodilator Agents/administration & dosage/adverse effects/*therapeutic use
EDAT- 1997/10/29 00:00
MHDA- 1997/10/29 00:01
CRDT- 1997/10/29 00:00
PHST- 1997/10/29 00:00 [pubmed]
PHST- 1997/10/29 00:01 [medline]
PHST- 1997/10/29 00:00 [entrez]
AID - 10.1177/000331979704801002 [doi]
PST - ppublish
SO  - Angiology. 1997 Oct;48(10):855-62. doi: 10.1177/000331979704801002.