PMID- 9343032
OWN - NLM
STAT- MEDLINE
DCOM- 19971120
LR  - 20131121
IS  - 0828-282X (Print)
IS  - 0828-282X (Linking)
VI  - 13
IP  - 9
DP  - 1997 Sep
TI  - Antihypertensive effects of perindopril treatment in adult spontaneously 
      hypertensive rats.
PG  - 831-5
AB  - OBJECTIVE: To determine the effect of perindopril treatment and treatment 
      withdrawal in the prevention of hypertension in adult male spontaneously 
      hypertensive rats (SHR). ANIMALS AND METHODS: Beginning at 15 weeks of age, male 
      SHR were treated with either distilled water (control) or different daily dosages 
      of perindopril (1, 2 or 4 mg/kg) by gavage for 10 weeks, followed by 10 weeks of 
      treatment withdrawal. Systolic blood pressure, heart rate and body weight of 
      adult SHR were determined at regular intervals before, during and after the 
      treatment withdrawal periods. At the end of the treatment withdrawal period, 
      plasma and tissue samples were taken for measurement of noradrenaline levels. 
      Angiotensin-converting enzyme (ACE) activity in the plasma from adult SHR and 
      Wistar-kyoto (WKY) rats treated with perindopril 4 mg/kg for two weeks was 
      measured by a radioassay method 6 and 24 h after treatment. RESULTS: Treatment 
      with perindopril caused a dose-dependent lowering of blood pressure in SHR during 
      the 10-week treatment. After withdrawal of the treatment, persistent lowering of 
      blood pressure was found in SHR treated with higher dosages (2 or 4 mg/kg), but 
      not in the 1 mg/kg group. There was no difference in the tissue level of 
      noradrenaline among the control group and SHR previously treated with 
      perindopril. In SHR and WKY treated with perindopril for two weeks, plasma level 
      of ACE activity was reduced longer than 24 h compared with their respective 
      controls. CONCLUSIONS: Chronic treatment of adult SHR with perindopril has a 
      dose-dependent effect on the blood pressure of these animals both during and 
      after withdrawal of treatment, but such a treatment had no long term effects on 
      the noradrenaline levels in various tissues.
FAU - Lee, R M
AU  - Lee RM
AD  - Department of Anaesthesia, Faculty of Health Sciences, McMaster University, 
      Hamilton, Ontario. rmkwlee@fhs.mcmaster.ca
FAU - Lu, M
AU  - Lu M
FAU - Gillies, L
AU  - Gillies L
FAU - Werstiuk, E S
AU  - Werstiuk ES
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Indoles)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Animals
MH  - Antihypertensive Agents/*therapeutic use
MH  - Blood Pressure/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hypertension/*prevention & control
MH  - Indoles/*therapeutic use
MH  - Male
MH  - Norepinephrine/blood
MH  - Peptidyl-Dipeptidase A/blood
MH  - Perindopril
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Time Factors
EDAT- 1997/10/29 00:00
MHDA- 1997/10/29 00:01
CRDT- 1997/10/29 00:00
PHST- 1997/10/29 00:00 [pubmed]
PHST- 1997/10/29 00:01 [medline]
PHST- 1997/10/29 00:00 [entrez]
PST - ppublish
SO  - Can J Cardiol. 1997 Sep;13(9):831-5.