PMID- 9343989
OWN - NLM
STAT- MEDLINE
DCOM- 19971113
LR  - 20041117
IS  - 0030-6096 (Print)
IS  - 0030-6096 (Linking)
VI  - 43
IP  - 1
DP  - 1997 Jun
TI  - Localization of manganese superoxide dismutase in the cerebral cortex and 
      hippocampus of Alzheimer-type senile dementia.
PG  - 1-5
AB  - Manganese-superoxide dismutase (Mn-SOD) was localized in the cerebral cortex and 
      hippocampus of patients with Alzheimer-type senile dementia (ATD) by 
      immunocytochemistry and the relationship of Mn-SOD with two major pathological 
      features of ATD, i.e., senile plaques and neurofibrillar tangles (NFTs), was 
      examined. Many astrocytes in senile plaques exhibited strong immunoreactivity for 
      both Mn-SOD and glial fibrillar acidic protein (GFAP) on serial section analysis. 
      This suggests that Mn-SOD scavenger system is associated with the formation of 
      senile plaques. On the other hand, Mn-SOD immunoreactivity was not significant in 
      NFT-loaded neurons.
FAU - Maeda, M
AU  - Maeda M
AD  - First Department of Anatomy, Osaka City University Medical School, Japan.
FAU - Takagi, H
AU  - Takagi H
FAU - Hattori, H
AU  - Hattori H
FAU - Matsuzaki, T
AU  - Matsuzaki T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Osaka City Med J
JT  - Osaka city medical journal
JID - 0376413
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*enzymology
MH  - Cerebral Cortex/*enzymology
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Hippocampus/*enzymology
MH  - Humans
MH  - Immunohistochemistry
MH  - Superoxide Dismutase/*analysis
EDAT- 1997/06/01 00:00
MHDA- 1997/10/31 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/10/31 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Osaka City Med J. 1997 Jun;43(1):1-5.