PMID- 9344643
OWN - NLM
STAT- MEDLINE
DCOM- 19980211
LR  - 20150831
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 36
IP  - 2
DP  - 1997 Aug
TI  - Effect of cytochalasin D on systemic and local anaphylaxis in a murine model.
PG  - 141-6
AB  - We investigated the effect of cytochalasin D on anaphylaxis. Cytochalasin D 
      dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in 
      rats. Especially, cytochalasin D inhibited compound 48/80-induced systemic 
      anaphylaxis 100% with a dose of 1 microg g-1 body weight (BW). Cytochalasin D 
      significantly inhibited serum histamine levels induced by compound 48/80. 
      Cytochalasin D (10(-1) microg g-1 BW) also inhibited local anaphylaxis activated 
      by anti-dinitrophenyl (DNP) IgE to 79.6+/-1.8%. Cytochalasin D dose-dependently 
      inhibited histamine release from the rat peritoneal mast cells activated by 
      compound 48/80 or anti-DNP IgE. The level of cAMP in rat peritoneal mast cells, 
      when cytochalasin D was added, transiently and significantly increased about 
      fourfold compared with that of basal cells. Our studies provide evidence that 
      cytochalasin D will be beneficial in the treatment of anaphylaxis.
CI  - Copyright 1997 The Italian Pharmacological Society.
FAU - Shin, H Y
AU  - Shin HY
AD  - College of Pharmacy, Wonkwang University, Iksan, South Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Shin, T Y
AU  - Shin TY
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Nucleic Acid Synthesis Inhibitors)
RN  - 22144-77-0 (Cytochalasin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - Q2WXR1I0PK (Cromolyn Sodium)
SB  - IM
MH  - Anaphylaxis/chemically induced/*prevention & control
MH  - Animals
MH  - Anti-Asthmatic Agents/therapeutic use
MH  - Cromolyn Sodium/therapeutic use
MH  - Cyclic AMP/*metabolism
MH  - Cytochalasin D/*therapeutic use
MH  - Histamine Release/*drug effects
MH  - Immunoglobulin E
MH  - Mast Cells/*drug effects/metabolism
MH  - Nucleic Acid Synthesis Inhibitors/*therapeutic use
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1997/08/01 00:00
MHDA- 1997/11/05 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/11/05 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - S1043-6618(97)90218-8 [pii]
AID - 10.1006/phrs.1997.0218 [doi]
PST - ppublish
SO  - Pharmacol Res. 1997 Aug;36(2):141-6. doi: 10.1006/phrs.1997.0218.