PMID- 9345449
OWN - NLM
STAT- MEDLINE
DCOM- 19971118
LR  - 20170214
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 1
IP  - 3
DP  - 1995 Nov
TI  - Clinical and subclinical neurological involvement in children of conjugal 
      multiple sclerosis patients.
PG  - 170-2
AB  - We report the occurrence of clinically definite multiple sclerosis in an 
      offspring of a couple with conjugal multiple sclerosis. Extensive investigation 
      of all members of this family, which includes two additional asymptomatic 
      children, eliminated the possibility of alternative neurological diagnoses. All 
      family members were studied with magnetic resonance imaging (MRI), evoked 
      potentials, and human leukocyte antigen (HLA) typing. An asymptomatic child had 
      subtle white matter abnormalities on MRI, suggesting subclinical neurological 
      involvement. This study documents the third case of multiple sclerosis in the 
      child of conjugal multiple sclerosis patients and provides the first report of 
      MRI lesions in an asymptomatic offspring of the same parents. Neurodiagnostic and 
      immunogenetic investigations of such rare family clusters may contribute to the 
      elucidation of the pathogenesis of multiple sclerosis.
FAU - Constantinescu, C S
AU  - Constantinescu CS
AD  - Department of Neurology, University of Pennsylvania School of Medicine, 
      Philadelphia, USA.
FAU - Grossman, R I
AU  - Grossman RI
FAU - Finelli, P F
AU  - Finelli PF
FAU - Kamoun, M
AU  - Kamoun M
FAU - Zmijewski, C
AU  - Zmijewski C
FAU - Cohen, J A
AU  - Cohen JA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Evoked Potentials/physiology
MH  - Family Health
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Marital Status
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/*genetics/immunology
MH  - Nervous System/*pathology
MH  - Nervous System Diseases/etiology/genetics/immunology
MH  - *Nuclear Family
MH  - *Parents
EDAT- 1995/11/01 00:00
MHDA- 1997/11/04 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1997/11/04 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1177/135245859500100307 [doi]
PST - ppublish
SO  - Mult Scler. 1995 Nov;1(3):170-2. doi: 10.1177/135245859500100307.