PMID- 9351592
OWN - NLM
STAT- MEDLINE
DCOM- 19971106
LR  - 20090929
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 156
IP  - 4 Pt 2
DP  - 1997 Oct
TI  - Epidemiological study of the genetics and environment of asthma, bronchial 
      hyperresponsiveness, and atopy: phenotype issues.
PG  - S123-9
AB  - The Epidemiological Study of the Genetics and Environment of Asthma (EGEA) 
      combined a case-control study and a family study. The total sample of 1,854 
      consisted of 348 patients with asthma selected through chest clinics and 416 
      control subjects and nuclear families ascertained through the cases. The protocol 
      included standardized questionnaires, bronchial responsiveness, allergen 
      skin-prick tests according to international protocols, total serum immunoglobulin 
      E (IgE) level measurements, and blood eosinophilia. Criteria used to select 
      subjects with asthma and determine asthma status of relatives for affected 
      sibling pair linkage analysis are described. Based on figures from the 348 asthma 
      cases of the EGEA study, issues relative to the definition of severe asthma and 
      intermediate phenotypes such as bronchial responsiveness and allergic markers are 
      discussed. Given the phenotypic heterogeneity involved, relevant phenotypes that 
      may lead to the detection of genetic factors will depend on the hypothesis 
      tested. Standardization of primary data and subphenotypes is a prerequisite for 
      pooling data, which will be needed in the future to better understand the 
      genetics and environmental factors of asthma.
FAU - Kauffmann, F
AU  - Kauffmann F
AD  - INSERM U169, Villejuif, France.
FAU - Dizier, M H
AU  - Dizier MH
FAU - Pin, I
AU  - Pin I
FAU - Paty, E
AU  - Paty E
FAU - Gormand, F
AU  - Gormand F
FAU - Vervloet, D
AU  - Vervloet D
FAU - Bousquet, J
AU  - Bousquet J
FAU - Neukirch, F
AU  - Neukirch F
FAU - Annesi, I
AU  - Annesi I
FAU - Oryszczyn, M P
AU  - Oryszczyn MP
FAU - Lathrop, M
AU  - Lathrop M
FAU - Demenais, F
AU  - Demenais F
FAU - Lockhart, A
AU  - Lockhart A
FAU - Feingold, J
AU  - Feingold J
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asthma/epidemiology/*genetics/physiopathology
MH  - Bronchial Hyperreactivity/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Family
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Hypersensitivity/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Severity of Illness Index
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
AID - 10.1164/ajrccm.156.4.12tac9 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S123-9. doi: 
      10.1164/ajrccm.156.4.12tac9.