PMID- 9351645
OWN - NLM
STAT- MEDLINE
DCOM- 19971222
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 8
IP  - 15
DP  - 1997 Oct 20
TI  - Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein 
      fragments.
PG  - 3213-7
AB  - The effects of beta-amyloid precursor protein (beta-APP) fragments on plasticity 
      of glutamtatergic synaptic transmission were examined in the hippocampus of 
      urethane anaesthetized rats. I.c.v. injection of beta-amyloid (A beta) 1-40 and 
      1-42 and the C-terminal fragment CT105 greatly shortened the duration of high 
      frequency stimulation-induced long-term potentiation (LTP) of field excitatory 
      postsynaptic potentials in the CA1 area. Whereas in vehicle injected animals LTP 
      was stable over a 5 h recording period, doses of these peptides (A beta 1-40, 0.4 
      and 3.5 nmol; A beta1-42, 0.01 nmol; CT105, 0.05 nmol) which did not affect 
      baseline synaptic transmission abolished LTP within 3-5 h. The reduced duration 
      of this form of synaptic plasticity may contribute to the cognitive deficits in 
      Alzheimer's disease.
FAU - Cullen, W K
AU  - Cullen WK
AD  - Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland.
FAU - Suh, Y H
AU  - Suh YH
FAU - Anwyl, R
AU  - Anwyl R
FAU - Rowan, M J
AU  - Rowan MJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Amyloid beta-Protein Precursor/administration & dosage/*pharmacology
MH  - Animals
MH  - Hippocampus/*drug effects
MH  - Injections, Intraventricular
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Synaptic Transmission/drug effects
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
AID - 10.1097/00001756-199710200-00006 [doi]
PST - ppublish
SO  - Neuroreport. 1997 Oct 20;8(15):3213-7. doi: 10.1097/00001756-199710200-00006.