PMID- 9352103
OWN - NLM
STAT- MEDLINE
DCOM- 19980113
LR  - 20190831
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 102
IP  - 2
DP  - 1997 Sep 20
TI  - Development of vomeronasal receptor neuron subclasses and establishment of 
      topographic projections to the accessory olfactory bulb.
PG  - 209-16
AB  - Previous studies of the adult vomeronasal system have shown that vomeronasal 
      receptor neurons in the middle layer (expressing Gi alpha 2) and deep layers 
      (expressing Go alpha) of the sensory epithelium project to the anterior and 
      posterior parts of the accessory olfactory bulb (AOB), respectively. In the 
      present study, the development of the two populations of vomeronasal receptor 
      neurons and their segregated projections were investigated in the opossum, 
      Monodelphis domestica. Antibodies to G proteins Gi alpha 2 and Go alpha were used 
      to identify the two subpopulations of receptor neurons. The Gi alpha 
      2-immunoreactive (ir) cells and Go alpha-ir cells appeared between postnatal day 
      0 (P0) and postnatal day 3 (P3) and both types of cells increased in number 
      during later development. The differential localization of Gi alpha 2-ir cells in 
      the middle layer and Go alpha-ir cells in the deep layer of the VNO could be seen 
      as early as P3 and became more prominent at later stages. The AOB was clearly 
      identified at P10, and at this stage segregated projections of Gi alpha 2-ir 
      fibers to the anterior part and Go alpha-ir fibers to the posterior part of the 
      AOB were seen. The segregation of the two types of fibers in the AOB resemble 
      that in the adult after P21. These results suggest that Gi alpha 2-ir and Go 
      alpha-ir subpopulations of receptor neurons in the VNO develop in parallel, and 
      that segregation of the two populations of receptor neurons in the VNO and the 
      topographic projection to the AOB are established at very early stages during 
      development.
FAU - Jia, C
AU  - Jia C
AD  - Program in Neural and Behavioral Sciences, State University of New York Health 
      Science Center, Brooklyn 11203, USA.
FAU - Goldman, G
AU  - Goldman G
FAU - Halpern, M
AU  - Halpern M
LA  - eng
GR  - DC 02745/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
SB  - IM
MH  - Animals
MH  - Brain Mapping/*methods
MH  - Embryonic and Fetal Development/physiology
MH  - Olfactory Bulb/embryology/growth & development/*physiology
MH  - Olfactory Pathways/physiology
MH  - Olfactory Receptor Neurons/*physiology
MH  - Opossums/*physiology
MH  - Vomeronasal Organ/embryology/growth & development/*physiology
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
AID - S0165380697000977 [pii]
AID - 10.1016/s0165-3806(97)00097-7 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1997 Sep 20;102(2):209-16. doi: 
      10.1016/s0165-3806(97)00097-7.