PMID- 9352792
OWN - NLM
STAT- MEDLINE
DCOM- 19971124
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 99
IP  - 1
DP  - 1997 Nov
TI  - A subset of gestational trophoblastic disease characterized by abnormal 
      chromosome 8 copy number detected by fluorescence in situ hybridization.
PG  - 24-9
AB  - The present paper describes the results of research conducted to ascertain 
      whether the report by Mark et al. [1], describing the concurrence of congenital 
      trisomy 8 mosaicism and gestational trophoblastic disease (GTD) in a 42 year-old 
      Gravida IV, Para IV patient was an isolated event. In contrast to other cases 
      described in the literature, the patient described in Mark et al. [1] had no 
      additional confounding chromosomal abnormalities other than trisomy 8. To the 
      best of our knowledge, ours was the only reported case of constitutional trisomy 
      8 mosaicism associated with gestational trophoblastic disease, a rare 
      gynecological disease entity. The question arises whether there exists a subset 
      of patients with GTD characterized by an abnormal chromosome 8 copy number. The 
      implicit hypothesis is that an abnormal number of chromosome 8 somehow 
      predisposes to cancer. A pilot study of 10 cases of GTD was conducted using 
      fluorescence in situ hybridization (FISH) and a commercial chromosome 8-specific 
      alpha-satellite probe on formalin-fixed, paraffin-embedded patient tissues. Among 
      eight informative cases successfully completed, two cases (25%) were found to be 
      trisomic, when a cut-off point of 10% trisomic cells is adopted. Another two 
      cases (25%) were found to be triploid. The results of our FISH study indicated 
      that an abnormal chromosome 8 copy number found in Mark et al. [1] is unlikely to 
      be an isolated event. Our data are consistent with the hypothesis that a subset 
      of GTD indeed may exist which is characterized by more than two copies of 
      chromosome 8. The present findings corroborate those recently found in breast, 
      prostate, and other cancers.
FAU - Mark, H F
AU  - Mark HF
AD  - Laboratory of Cytogenetics, FISH and Genotoxicology, Rhode Island Hospital, 
      Providence 02903, USA.
FAU - Afify, A
AU  - Afify A
FAU - Taylor, W
AU  - Taylor W
FAU - Santoro, K
AU  - Santoro K
FAU - Lathrop, J C
AU  - Lathrop JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Pilot Projects
MH  - Pregnancy
MH  - Trisomy
MH  - Trophoblastic Neoplasms/*genetics/pathology
MH  - Uterine Neoplasms/*genetics/pathology
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
AID - S0165460896004396 [pii]
AID - 10.1016/s0165-4608(96)00439-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Nov;99(1):24-9. doi: 10.1016/s0165-4608(96)00439-6.