PMID- 9353055
OWN - NLM
STAT- MEDLINE
DCOM- 19971113
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 65
IP  - 11
DP  - 1997 Nov
TI  - Differences in coughing and other responses to intrabronchial infection with 
      Bordetella pertussis among strains of rats.
PG  - 4711-7
AB  - Four strains of rats were each infected intrabronchially with approximately 10(8) 
      CFU of Bordetella pertussis 18-323 encased in fine agarose beads. After 8 days, 
      Sprague-Dawley rats developed the highest incidence of coughing paroxysms, as 
      monitored with voice-activated tape recorders; Brown Norway, Lewis, and Hooded 
      Lister rats coughed significantly less frequently. Marked leukocytosis, with 
      counts up to four times the normal levels, and retardation of normal weight gain 
      occurred in all four rat strains. Both coughing and leukocytosis were greater in 
      animals that were infected at 4 weeks of age than in those infected at 6 weeks of 
      age. Total serum immunoglobulin E (IgE) rose in all four rat strains 9- to 
      244-fold by day 8 after infection and returned to near preinfection levels at 6 
      weeks. Sprague-Dawley and Lewis rats, which had the lowest basal levels of total 
      IgE in serum, showed the greatest degrees of elevation. All four rat strains had 
      IgG to B. pertussis whole-cell sonicate and to filamentous hemagglutinin in 
      6-week-postinfection sera. However, the strains differed in production of IgG to 
      pertussis toxin, with Sprague-Dawley rats having the highest titers and Hooded 
      Lister and Lewis rats being nonresponders. These studies highlight the importance 
      of rat strain as a variable in the coughing-rat model of pertussis and validate 
      the choice of the Sprague-Dawley rats in previous studies.
FAU - Hall, E
AU  - Hall E
AD  - Division of Infection and Immunity, Institute of Biomedical and Life Sciences, 
      University of Glasgow, United Kingdom.
FAU - Parton, R
AU  - Parton R
FAU - Wardlaw, A C
AU  - Wardlaw AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antibodies, Bacterial/biosynthesis
MH  - Bordetella pertussis/immunology
MH  - Cough/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Leukocytosis/etiology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Rats, Inbred Lew
MH  - Rats, Sprague-Dawley
MH  - Species Specificity
MH  - Weight Gain
MH  - Whooping Cough/*immunology
PMC - PMC175676
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
PMCR- 1997/11/01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
PHST- 1997/11/01 00:00 [pmc-release]
AID - 10.1128/iai.65.11.4711-4717.1997 [doi]
PST - ppublish
SO  - Infect Immun. 1997 Nov;65(11):4711-7. doi: 10.1128/iai.65.11.4711-4717.1997.