PMID- 9353147
OWN - NLM
STAT- MEDLINE
DCOM- 19971120
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 110
IP  - 1
DP  - 1997 Oct
TI  - Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against 
      cathepsin G.
PG  - 41-4
AB  - Autoantibodies of diverse specificities are detected in sera of patients with 
      acute malaria. The clinical relevance of these autoantibodies is not clear, 
      though there are reports associating some autoantibodies with specific disease 
      manifestations. We have investigated the occurrence of ANCA in the sera of 93 
      patients during episodes of acute malaria. Sera were tested by indirect 
      immunofluorescence (IIF) and by ELISA for antibodies to neutrophil cytoplasmic 
      components proteinase 3 (PR3), myeloperoxidase (MPO), cathepsin G (CG), human 
      leucocyte elastase (HLE), and lactoferrin (LF). Forty-seven sera samples (50.5%) 
      were positive by IIF, all except one with the atypical ANCA pattern (a-ANCA). 
      When screened by ELISA, anti-CG antibodies were detected in 52 samples (56%), 
      while anti-PR3 and anti-MPO antibodies were detected in three and one samples, 
      respectively. Antibody binding to HLE and LF was not significant. Anti-CG 
      antibodies were detected in 93% of the IIF-positive sera. A combination of 
      anti-CG and anti-PR3 antibodies was noted in three samples. Our study 
      demonstrates the presence of ANCA in sera from patients with acute malaria, 
      almost all with the a-ANCA pattern on IIF. The antibody specificity, noted for 
      the first time in our study, appears to be predominantly directed against CG. The 
      significance of CG and CG-ANCA in the pathogenesis and clinical manifestations of 
      malaria has yet to be elucidated.
FAU - Yahya, T M
AU  - Yahya TM
AD  - Department of Internal Medicine, Faculty of Medicine & Health Sciences, UAE 
      University, Al Ain, United Arab Emirates.
FAU - Benedict, S
AU  - Benedict S
FAU - Shalabi, A
AU  - Shalabi A
FAU - Bayoumi, R
AU  - Bayoumi R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Autoantibodies)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.20 (CTSG protein, human)
RN  - EC 3.4.21.20 (Cathepsin G)
SB  - IM
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Antibody Specificity
MH  - Autoantibodies/*immunology
MH  - Cathepsin G
MH  - Cathepsins/*immunology
MH  - Humans
MH  - Malaria/*immunology
MH  - Serine Endopeptidases
PMC - PMC1904799
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
PMCR- 1998/10/01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
PHST- 1998/10/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1997.4981395.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1997 Oct;110(1):41-4. doi: 10.1046/j.1365-2249.1997.4981395.x.