PMID- 9353420
OWN - NLM
STAT- MEDLINE
DCOM- 19971208
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 283
IP  - 2
DP  - 1997 Nov
TI  - Activation of metabotropic glutamate receptors in the rat nucleus accumbens 
      increases locomotor activity in a dopamine-dependent manner.
PG  - 962-8
AB  - The effect on locomotor activity of in vivo activation of metabotropic glutamate 
      receptors (mGluRs) in the nucleus accumbens (NAcc) was investigated in rats. 
      Bilateral intracranial microinjections into the NAcc of the selective mGluR 
      agonist, 1-aminocyclopentane-trans-1,3-dicarboxylic acid [(1S,3R)-ACPD], were 
      made in the freely moving rat and locomotor activity was subsequently measured 
      for 2 hr. Different groups of rats injected with one of four doses of 
      (1S,3R)-ACPD (0.005, 0.05, 0.5, or 2.5 nmol/0.5 microl/side) showed significant 
      dose-dependent increases in both horizontal and vertical locomotor activity 
      relative to control rats that received injections of the saline vehicle. 
      Time-course analyses revealed that these effects, in a manner similar to the 
      locomotor hyperactivity produced by the injection of amphetamine into the NAcc, 
      were most pronounced in the initial 30 min after injection and no longer present 
      after 1 hr of testing. These locomotor-activating effects of (1S,3R)-ACPD were 
      blocked by the co-injection of the mGluR antagonist, 
      (RS)-alpha-methyl-4-carboxyphenylglycine (2.5 nmol/side), as well as of the 
      dopamine receptor antagonist, fluphenazine (2.0 or 9.8 nmol/side), which suggests 
      that they depend on dopamine neurotransmission. These findings indicate that 
      mGluRs play an important role in the production of locomotor behaviors involving 
      DA-excitatory amino acid interactions in the NAcc.
FAU - Kim, J H
AU  - Kim JH
AD  - Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, 
      C 3077, Chicago, IL 60637, USA.
FAU - Vezina, P
AU  - Vezina P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Dopamine/*physiology
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Microinjections
MH  - Motor Activity/*drug effects
MH  - Nucleus Accumbens/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Metabotropic Glutamate/*physiology
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1997 Nov;283(2):962-8.