PMID- 9354421
OWN - NLM
STAT- MEDLINE
DCOM- 19971120
LR  - 20041117
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 57
IP  - 21
DP  - 1997 Nov 1
TI  - Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and 
      insulinomas.
PG  - 4682-6
AB  - Gastrinomas and insulinomas are frequent in multiple endocrine neoplasia type 1 
      (MEN1). The MEN1 tumor suppressor gene was recently identified. To elucidate the 
      etiological role of the MEN1 gene in sporadic enteropancreatic endocrine 
      tumorigenesis, we analyzed tumors (28 gastrinomas and 12 insulinomas) from 40 
      patients for MEN1 gene mutations and allelic deletions. One copy of the MEN1 gene 
      was found to be deleted in 25 of 27 (93%) sporadic gastrinomas and in 6 of 12 
      (50%) sporadic insulinomas. MEN1 gene mutations were identified in 9 of 27 (33%) 
      sporadic gastrinomas and 2 of 12 (17%) insulinomas and were not seen in 
      corresponding germ-line DNA sequence. A specific MEN1 mutation was detected in 
      one gastrinoma and in the corresponding germ-line DNA of a patient who had no 
      family history of MEN1. Somatic MEN1 gene mutations and deletions play a critical 
      role in the tumorigenesis of sporadic gastrinomas and may also contribute to the 
      development of a subgroup of insulinomas.
FAU - Zhuang, Z
AU  - Zhuang Z
AD  - Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 
      20892, USA.
FAU - Vortmeyer, A O
AU  - Vortmeyer AO
FAU - Pack, S
AU  - Pack S
FAU - Huang, S
AU  - Huang S
FAU - Pham, T A
AU  - Pham TA
FAU - Wang, C
AU  - Wang C
FAU - Park, W S
AU  - Park WS
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Debelenko, L V
AU  - Debelenko LV
FAU - Kester, M
AU  - Kester M
FAU - Guru, S C
AU  - Guru SC
FAU - Manickam, P
AU  - Manickam P
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Yu, F
AU  - Yu F
FAU - Heppner, C
AU  - Heppner C
FAU - Crabtree, J S
AU  - Crabtree JS
FAU - Skarulis, M C
AU  - Skarulis MC
FAU - Venzon, D J
AU  - Venzon DJ
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
FAU - Collins, F S
AU  - Collins FS
FAU - Burns, A L
AU  - Burns AL
FAU - Marx, S J
AU  - Marx SJ
FAU - Lubensky, I A
AU  - Lubensky IA
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Gastrinoma/*genetics
MH  - Gene Deletion
MH  - Genes, Tumor Suppressor/*genetics
MH  - Germ-Line Mutation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Insulinoma/*genetics
MH  - Jejunal Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation/*genetics
MH  - Pancreatic Neoplasms/*genetics
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1997 Nov 1;57(21):4682-6.