PMID- 935513
OWN - NLM
STAT- MEDLINE
DCOM- 19760901
LR  - 20190823
IS  - 0090-6980 (Print)
IS  - 0090-6980 (Linking)
VI  - 11
IP  - 5
DP  - 1976 May
TI  - Inhibitory actions of polyphloretin phosphate and related compounds on the 
      response to prostaglandin in the smooth muscle of guinea-pig stomach.
PG  - 829-40
AB  - The inhibitory actions of polyphloretin phosphate (PPP) and related compounds, 
      di-4-phloretin phosphate (DPP), PHLORETIN AND TRIHYDROXY PROPIOPHENONE (THPP) on 
      the contractile responses to prostaglandin (PG) and acetylcholine (ACh) in 
      longitudinal smooth muscle of guinea-pig stomach were studied. Of the four 
      inhibitors PPP and DPP showed relatively selective antagonism for PGE1. DPP gave 
      the highest pW2 value against PGE1. These results indicate that DPP is a useful 
      antagonist of PG in smooth muscle, although it slightly inhibits responses to 
      ACh, 5-HT or histamine, and the Ca-induced contracture in K depolarized 
      preparation.
FAU - Ishizawa, M
AU  - Ishizawa M
FAU - Miyazaki, E
AU  - Miyazaki E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prostaglandins
JT  - Prostaglandins
JID - 0320271
RN  - 0 (Propiophenones)
RN  - 0 (Prostaglandins E)
RN  - 0 (Prostaglandins F)
RN  - 820484N8I3 (Histamine)
RN  - 9014-72-6 (Polyphloretin Phosphate)
RN  - N9YNS0M02X (Acetylcholine)
RN  - S5J5OE47MK (Phloretin)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Guinea Pigs
MH  - Histamine/pharmacology
MH  - Muscle Contraction/*drug effects
MH  - Muscle, Smooth/*drug effects
MH  - Phloretin/*analogs & derivatives
MH  - Polyphloretin Phosphate/*pharmacology
MH  - Propiophenones/pharmacology
MH  - Prostaglandins E/*pharmacology
MH  - Prostaglandins F/*pharmacology
MH  - Stomach/*drug effects
EDAT- 1976/05/01 00:00
MHDA- 1976/05/01 00:01
CRDT- 1976/05/01 00:00
PHST- 1976/05/01 00:00 [pubmed]
PHST- 1976/05/01 00:01 [medline]
PHST- 1976/05/01 00:00 [entrez]
AID - 0090-6980(76)90190-8 [pii]
AID - 10.1016/0090-6980(76)90190-8 [doi]
PST - ppublish
SO  - Prostaglandins. 1976 May;11(5):829-40. doi: 10.1016/0090-6980(76)90190-8.