PMID- 9357055
OWN - NLM
STAT- MEDLINE
DCOM- 19980105
LR  - 20190818
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 18
IP  - 7
DP  - 1997
TI  - Role of brain angiotensin in thirst and sodium appetite of rats.
PG  - 977-84
AB  - The role of brain angiotensin II (ANG II) in water, Na and food intake of rats 
      was studied. Intracerebroventricular (i.c.v.) infusion (100 micrograms/h) of the 
      non-peptide ANG II receptor antagonist losartan (type 1), but not PD123319 (type 
      2), completely blocked water intake caused by i.c.v. infusion of ANG II at 50 
      ng/h. Following food deprivation, food intake was reduced by PD123319 and 
      associated water intake was decreased by losartan or PD123319. Neither water 
      intake after water deprivation nor Na intake after Na depletion was altered by 
      losartan or PD123319. In conclusion, evidence was consistent with a role for 
      brain ANG II in both food and water intake after food deprivation but not in 
      thirst subsequent to water deprivation or Na intake after Na depletion alone.
FAU - Weisinger, R S
AU  - Weisinger RS
AD  - Howard Florey Institute of Experimental Physiology and Medicine, University of 
      Melbourne, Parkville VIC, Australia. 
      richard_weisinger.hfi;camuwaye.unimelb.edu.au
FAU - Blair-West, J R
AU  - Blair-West JR
FAU - Burns, P
AU  - Burns P
FAU - Denton, D A
AU  - Denton DA
FAU - Tarjan, E
AU  - Tarjan E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Pyridines)
RN  - 0 (Sodium, Dietary)
RN  - 11128-99-7 (Angiotensin II)
RN  - 130663-39-7 (PD 123319)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - 9NEZ333N27 (Sodium)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin II/*physiology
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - Appetite/drug effects/*physiology
MH  - Brain/*physiology
MH  - Drinking/drug effects/physiology
MH  - Eating/drug effects/physiology
MH  - Furosemide/pharmacology
MH  - Imidazoles/administration & dosage/pharmacology
MH  - Injections, Intraventricular
MH  - Losartan/administration & dosage/pharmacology
MH  - Male
MH  - Pyridines/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Renin-Angiotensin System/drug effects/physiology
MH  - Sodium/metabolism
MH  - Sodium, Dietary/administration & dosage
MH  - Thirst/drug effects/*physiology
EDAT- 1997/01/01 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0196-9781(97)00077-6 [pii]
AID - 10.1016/s0196-9781(97)00077-6 [doi]
PST - ppublish
SO  - Peptides. 1997;18(7):977-84. doi: 10.1016/s0196-9781(97)00077-6.