PMID- 9357182
OWN - NLM
STAT- MEDLINE
DCOM- 19971216
LR  - 20191126
IS  - 0254-8860 (Print)
IS  - 0254-8860 (Linking)
VI  - 16
IP  - 4
DP  - 1997 Oct
TI  - Does Entamoeba histolytica cause irritable bowel syndrome?
PG  - 130-3
AB  - BACKGROUND: Symptoms of patients with irritable bowel syndrome (IBS) closely 
      mimic those of patients with non-dysenteric amebic colitis. AIM: To examine the 
      clinical relevance of presence and types of Entamoeba histolytica in stools of 
      patients with IBS. METHODS: IBS was diagnosed by Manning's criteria. Stool 
      examination was done 4-weekly for 48 weeks to detect E. histolytica cysts or 
      trophozoites. Patients underwent initial sigmoidoscopy. Sera of 22 IBS patients, 
      23 asymptomatic cyst passers and 36 healthy volunteers whose stools were also 
      examined were tested for presence of antiamebic antibodies. Stools were cultured 
      for amebae; positive cultures were subjected to polyacrylamide-gel 
      electrophoresis (PAGE) using hexokinase (HK) isoenzyme to distinguish between 
      pathogenic (fast-moving band) E. histolytica infection and nonpathogenic (slow 
      band) species of Entamoeba dispar. RESULTS: E. histolytica cultured from stool 
      samples of four IBS patients had slow-moving band of HK on PAGE. All patients 
      spontaneously eradicated the infection during the next eight to 24 weeks; all had 
      negative serology for antiamebic antibodies, and normal rectal mucosa on 
      sigmoidoscopy. No change in symptom score occurred on follow up in IBS patients, 
      although all of them cleared the infection. Three additional E. histolytica 
      isolates from IBS patients obtained from another laboratory also showed 
      nonpathogenic isoenzyme pattern. CONCLUSION: Bowel symptoms in IBS patients were 
      not related to E. histolytica infection. The term non-dysenteric amebic colitis 
      thus appears to be inappropriate, since it may be used erroneously for patients 
      with IBS with nonpathogenic ameba, leading to injudicious treatment with 
      antiamebic drugs.
FAU - Sinha, P
AU  - Sinha P
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow.
FAU - Ghoshal, U C
AU  - Ghoshal UC
FAU - Choudhuri, G
AU  - Choudhuri G
FAU - Naik, S
AU  - Naik S
FAU - Ayyagari, A
AU  - Ayyagari A
FAU - Naik, S R
AU  - Naik SR
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
SB  - IM
CIN - Indian J Gastroenterol. 1997 Oct;16(4):127-9. PMID: 9357181
MH  - Abdominal Pain/*etiology
MH  - Adult
MH  - Animals
MH  - Colonic Diseases, Functional/diagnosis/epidemiology/*etiology
MH  - *Developing Countries
MH  - Diagnosis, Differential
MH  - *Entamoeba histolytica
MH  - Entamoebiasis/*complications/diagnosis/epidemiology
MH  - Feces/parasitology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - India/epidemiology
MH  - Leprosy/rehabilitation
MH  - Male
MH  - Parasite Egg Count
MH  - Rehabilitation Centers
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
PST - ppublish
SO  - Indian J Gastroenterol. 1997 Oct;16(4):130-3.