PMID- 9357800
OWN - NLM
STAT- MEDLINE
DCOM- 19971121
LR  - 20190611
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 273
IP  - 4
DP  - 1997 Oct
TI  - Caloric restriction increases HDL2 levels in rhesus monkeys (Macaca mulatta).
PG  - E714-9
LID - 10.1152/ajpendo.1997.273.4.E714 [doi]
AB  - Caloric restriction (CR) prolongs the life of rodents and other small animals, 
      but the benefits of CR for primates and people are as yet unknown, and mechanisms 
      by which CR may slow aging remain unidentified. A study of rhesus monkeys, Macaca 
      mulatta, is underway to determine if CR might prolong life span in primates and 
      to evaluate potential mechanisms for life prolongation. Thirty rhesus monkeys in 
      three age cohorts, restricted to 70% of ad libitum calorie intake for 6-7 yr, 
      were compared with 30 controls. Plasma lipid, lipoprotein, and high-density 
      lipoprotein (HDL) apolipoproteins and subfractions were measured and compared 
      with weight, percent fat, glucose, and insulin level. CR caused decreased 
      triglyceride levels in adult monkeys and increased levels of HDL2b, the HDL 
      subfraction associated with protection from atherosclerosis. Multivariate 
      statistical analyses showed that differences in lipid and lipoprotein levels 
      occurring with CR could be accounted for, at least in part, by decreased body 
      mass and improved glucose regulation. These studies have used a novel dietary 
      modification paradigm in nonhuman primates focused on calorie reduction. Results 
      suggest that CR, as mediated by its beneficial effect on body composition and 
      glucose metabolism, could prolong human life by decreasing the incidence of 
      atherosclerosis.
FAU - Verdery, R B
AU  - Verdery RB
AD  - Arizona Center on Aging, Tucson 85719, USA.
FAU - Ingram, D K
AU  - Ingram DK
FAU - Roth, G S
AU  - Roth GS
FAU - Lane, M A
AU  - Lane MA
LA  - eng
GR  - K01-AG-00414/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Apolipoprotein A-II)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, HDL2)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aging/*blood
MH  - Animals
MH  - Apolipoprotein A-I/blood
MH  - Apolipoprotein A-II/blood
MH  - Body Composition
MH  - Body Mass Index
MH  - Body Weight
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - *Diet, Reducing
MH  - Humans
MH  - Lipoproteins, HDL/*blood
MH  - Lipoproteins, HDL2
MH  - Macaca mulatta
MH  - Male
MH  - Triglycerides/blood
EDAT- 1997/11/14 00:00
MHDA- 1997/11/14 00:01
CRDT- 1997/11/14 00:00
PHST- 1997/11/14 00:00 [pubmed]
PHST- 1997/11/14 00:01 [medline]
PHST- 1997/11/14 00:00 [entrez]
AID - 10.1152/ajpendo.1997.273.4.E714 [doi]
PST - ppublish
SO  - Am J Physiol. 1997 Oct;273(4):E714-9. doi: 10.1152/ajpendo.1997.273.4.E714.