PMID- 9361104
OWN - NLM
STAT- MEDLINE
DCOM- 19971204
LR  - 20190914
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 47
IP  - 10
DP  - 1997 Oct
TI  - A case of lymphoid interstitial pneumonia in a 3-month-old boy not associated 
      with HIV infection: immunohistochemistry of lung biopsy specimens and serum 
      transforming growth factor-beta 1 assay.
PG  - 698-702
AB  - The case of a 3-month-old boy with lymphoid interstitial pneumonia (LIP) is 
      reported. He had cough and tachypnea, his weight gain was poor and a chest 
      radiograph showed microgranular shadows in almost all lung areas. Histological 
      investigations revealed severe cellular infiltration by a variety of lymphoid and 
      plasma cells with lymphoid follicle formation in the alveolar walls and also 
      around the bronchioles. Foamy macrophages, a few lymphocytes and exudate filled 
      the alveolar spaces. Epithelial cells lining the air spaces expressed human 
      leukocyte antigen (HLA)-DR. Lymphocytes and macrophages in the alveolar spaces 
      expressed transforming growth factor (TGF)-beta strongly. Serum TGF-beta 1 
      concentrations were measured eight times during the course of his illness. They 
      exceeded the upper end of the normal range in four samples and were within it in 
      the others. These results suggested that dysfunction of the immune system, 
      especially abnormal expression of HLA-DR in non-immune cells and exaggerated 
      production of TGF-beta played important roles in the pathogenesis of LIP in this 
      patient.
FAU - Koga, M
AU  - Koga M
AD  - Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan.
FAU - Umemoto, Y
AU  - Umemoto Y
FAU - Nishikawa, M
AU  - Nishikawa M
FAU - Nakashima, K
AU  - Nakashima K
FAU - Ishihara, T
AU  - Ishihara T
FAU - Furukawa, S
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD20)
RN  - 0 (CD79 Antigens)
RN  - 0 (CD79A protein, human)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Antigens, CD20/analysis
MH  - Biopsy
MH  - CD79 Antigens
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Lung/chemistry/diagnostic imaging/*pathology
MH  - Lung Diseases, Interstitial/diagnostic imaging/*pathology
MH  - Lymphocytes/cytology
MH  - Macrophages/cytology
MH  - Male
MH  - Radiography
MH  - Receptors, Antigen, B-Cell/analysis
MH  - Transforming Growth Factor beta/blood
EDAT- 1997/11/15 00:00
MHDA- 1997/11/15 00:01
CRDT- 1997/11/15 00:00
PHST- 1997/11/15 00:00 [pubmed]
PHST- 1997/11/15 00:01 [medline]
PHST- 1997/11/15 00:00 [entrez]
AID - 10.1111/j.1440-1827.1997.tb04444.x [doi]
PST - ppublish
SO  - Pathol Int. 1997 Oct;47(10):698-702. doi: 10.1111/j.1440-1827.1997.tb04444.x.