PMID- 9361945
OWN - NLM
STAT- MEDLINE
DCOM- 19971212
LR  - 20221207
IS  - 0902-0063 (Print)
IS  - 0902-0063 (Linking)
VI  - 11
IP  - 5 Pt 2
DP  - 1997 Oct
TI  - HLA-DQ matching in cadaveric renal transplantation.
PG  - 480-4
AB  - The impact of matching for the human leukocyte antigen (HLA)-DQ phenotype in 
      cadaveric renal transplantation is unclear. We analyzed the effect of matching 
      serologically defined HLA-DQ phenotypes on renal allograft survival in 12,050 
      first cadaveric renal transplants (recipients were 63.5% white and 36.5% 
      African-American). Recipients were entered into the South-Eastern Organ 
      Procurement Foundation (SEOPF) database between 1 October 1987 and 6 June 1995. A 
      series of life table analyses were done to test the equality of survival curves 
      for HLA-DQ match, both alone and accommodating for differences in recipient race 
      and HLA-DR match. Cox regression models were then performed to detect differences 
      in allograft survival based upon HLA-DQ match. Initial adjustments were done by 
      recipient race. Subsequent adjustments were done by recipient and donor race, age 
      and sex, cold ischemia time (CIT), body mass index (BMI), cyclosporine A (CyA) 
      use, peak panel reactive antibody (PRA) titer, year of transplant, presence of 
      diabetes mellitus (DM), and degree of HLA-A,B and HLA-DR match as covariates. The 
      effect of varying degrees of HLA-DQ match on graft survival were similar between 
      the two races (p = 0.87). In all recipients, an 8.3% reduction in graft failure 
      was observed for each increase in HLA-DQ match using the Cox regression model 
      adjusted only for recipient race (p = 0.004). A non-significant 3.0% reduction in 
      graft failure (p = 0.38) was observed for each level of increasing HLA-DQ match 
      when using the Cox regression model adjusted for recipient and donor race, age 
      and sex, CIT, BMI, CyA use, year of transplant, DM, HLA-A,B and -DR match. In 
      this model, superior HLA-A,B match and HLA-DR match, recipient and donor age, 
      male donor sex, shorter CIT, white race of recipient, lower peak PRA, CyA use, 
      and absence of DM significantly improved graft survival (all < or = 0.004). We 
      conclude that HLA-DQ matching does not significantly affect cadaveric renal 
      allograft survival once adjusted for other known predictors of graft outcome.
FAU - Freedman, B I
AU  - Freedman BI
AD  - Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, 
      Winston-Salem, North Carolina 27157-1053, USA.
FAU - Thacker, L R
AU  - Thacker LR
FAU - Heise, E R
AU  - Heise ER
FAU - Adams, P L
AU  - Adams PL
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Antibodies)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Age Factors
MH  - Antibodies/analysis
MH  - Black People/genetics
MH  - Body Mass Index
MH  - Cadaver
MH  - Cold Temperature
MH  - Cyclosporine/therapeutic use
MH  - Databases as Topic
MH  - Diabetes Mellitus/surgery
MH  - Female
MH  - Forecasting
MH  - Graft Survival
MH  - HLA-A Antigens/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - *Histocompatibility
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Transplantation/*immunology
MH  - Life Tables
MH  - Male
MH  - Organ Preservation
MH  - Phenotype
MH  - Proportional Hazards Models
MH  - Sex Factors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - White People/genetics
EDAT- 1997/11/15 00:00
MHDA- 1997/11/15 00:01
CRDT- 1997/11/15 00:00
PHST- 1997/11/15 00:00 [pubmed]
PHST- 1997/11/15 00:01 [medline]
PHST- 1997/11/15 00:00 [entrez]
PST - ppublish
SO  - Clin Transplant. 1997 Oct;11(5 Pt 2):480-4.