PMID- 9362535
OWN - NLM
STAT- MEDLINE
DCOM- 19971203
LR  - 20220318
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 186
IP  - 10
DP  - 1997 Nov 17
TI  - Defects in macrophage recruitment and host defense in mice lacking the CCR2 
      chemokine receptor.
PG  - 1757-62
AB  - Chemokines are a structurally related family of cytokines that are important for 
      leukocyte trafficking. The C-C chemokine monocyte chemoattractant protein-1 
      (MCP-1) is a potent monocyte activator in vitro and has been associated with 
      monocytic infiltration in several inflammatory diseases. One C-C chemokine 
      receptor, CCR2, has been identified that mediates in vitro responses to MCP-1 and 
      its close structural homologues. CCR2 has also recently been demonstrated to be a 
      fusion cofactor for several HIV isolates. To investigate the normal physiological 
      function of CCR2, we generated mice with a targeted disruption of the ccr2 gene. 
      Mice deficient for CCR2 developed normally and had no hematopoietic 
      abnormalities. However, ccr2(-/-) mice failed to recruit macrophages in an 
      experimental peritoneal inflammation model. In addition, these mice were unable 
      to clear infection by the intracellular bacteria, Listeria monocytogenes. These 
      results suggest that CCR2 has a nonredundant role as a major mediator of 
      macrophage recruitment and host defense against bacterial pathogens and that 
      MCP-1 and other CCR2 ligands are effectors of those functions.
FAU - Kurihara, T
AU  - Kurihara T
AD  - Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, 
      Princeton, New Jersey 08543-4000, USA.
FAU - Warr, G
AU  - Warr G
FAU - Loy, J
AU  - Loy J
FAU - Bravo, R
AU  - Bravo R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - Cell Movement/*genetics/*immunology
MH  - Female
MH  - Immunity, Innate/genetics
MH  - Listeria monocytogenes/growth & development/immunology
MH  - Listeriosis/genetics/microbiology/pathology
MH  - Macrophages/*immunology/metabolism/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Mice, Knockout
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/*deficiency/*genetics
PMC - PMC2199145
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
PMCR- 1998/05/17
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
PHST- 1998/05/17 00:00 [pmc-release]
AID - 10.1084/jem.186.10.1757 [doi]
PST - ppublish
SO  - J Exp Med. 1997 Nov 17;186(10):1757-62. doi: 10.1084/jem.186.10.1757.