PMID- 9363921
OWN - NLM
STAT- MEDLINE
DCOM- 19971204
LR  - 20181201
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 114 Suppl 1
DP  - 1997 Oct
TI  - Enhanced production of RANTES, an eosinophil chemoattractant factor, by 
      cytokine-stimulated epidermal keratinocytes.
PG  - 28-32
AB  - In allergic skin diseases such as atopic dermatitis (AD), eosinophils migrate 
      from the circulation to the skin. We investigated the mechanisms of eosinophil 
      chemotaxis in atopic dermatitis by examining the effect of stimulation of 
      epidermal keratinocytes (KC) by inflammatory cytokines, interferon-gamma 
      (IFNgamma) and/or tumor necrosis factor-alpha (TNF alpha) on the production of 
      eosinophil chemotactic factors. Simultaneous addition of IFNgamma and TNF alpha 
      to culture KC synergistically increased eosinophil chemotaxis and the expression 
      of RANTES mRNA and protein level on these cells. Anti-RANTES antibody blocked 
      eosinophil chemotaxis by IFNgamma- and TNF alpha-stimulated KC. Our results 
      indicate that the production of RANTES by KC may help to explain eosinophil 
      infiltration into the skin in AD.
FAU - Yamada, H
AU  - Yamada H
AD  - Department of Dermatology, Kinki University School of Medicine, Osakasayama, 
      Osaka, Japan.
FAU - Matsukura, M
AU  - Matsukura M
FAU - Yudate, T
AU  - Yudate T
FAU - Chihara, J
AU  - Chihara J
FAU - Stingl, G
AU  - Stingl G
FAU - Tezuka, T
AU  - Tezuka T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Chemokine CCL5/*biosynthesis
MH  - Chemotactic Factors, Eosinophil/*biosynthesis
MH  - Cytokines/*immunology
MH  - Dermatitis, Atopic/immunology
MH  - Epidermal Cells
MH  - Epidermis/metabolism
MH  - Female
MH  - Humans
MH  - Interferon-gamma/immunology
MH  - Keratinocytes/cytology/drug effects/*immunology
MH  - Skin/cytology/metabolism
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 1997/11/18 00:00
MHDA- 1997/11/18 00:01
CRDT- 1997/11/18 00:00
PHST- 1997/11/18 00:00 [pubmed]
PHST- 1997/11/18 00:01 [medline]
PHST- 1997/11/18 00:00 [entrez]
AID - 10.1159/000237713 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1997 Oct;114 Suppl 1:28-32. doi: 10.1159/000237713.