PMID- 9365111
OWN - NLM
STAT- MEDLINE
DCOM- 19971208
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 62
IP  - 5
DP  - 1997 Nov
TI  - In vivo properties of monocyte chemoattractant protein-1.
PG  - 577-80
AB  - Monocyte chemoattractant protein-1 (MCP-1) attracts monocytes, memory T 
      lymphocytes, and natural killer (NK) cells in vitro. Its expression has been 
      documented in disorders characterized by mononuclear cell infiltrates, suggesting 
      that it may contribute to the inflammatory component of such diseases as 
      atherosclerosis, multiple sclerosis, or rheumatoid arthritis. To prove a causal 
      association, the in vivo properties of MCP-1 must be understood. Several lines of 
      transgenic mice have been constructed to address this question. A transgenic line 
      in which MCP-1 expression is controlled by the MMTV-LTR expressed high levels of 
      MCP-1 in multiple organs but showed no evidence for monocyte infiltration. 
      Instead, these mice were more susceptible to infection by the intracellular 
      pathogens, Listeria monocytogenes and Mycobacterium tuberculosis. These mice had 
      high serum levels of MCP-1, suggesting that their circulating monocytes may have 
      been desensitized or that MCP-1 stimulated a Th2-dominant response. In contrast, 
      another model in which MCP-1 expression was controlled by the insulin promoter 
      demonstrated a monocytic infiltrate in pancreatic islets. These results indicate 
      that MCP-1 expression at low levels in an anatomically confined area results in 
      monocyte infiltration, suggesting that when properly expressed, MCP-1's in vitro 
      properties are reproduced in vivo. This justifies the examination of 
      MCP-1-deficient mice in disease models in order to explore MCP-1's role in 
      pathogenesis.
FAU - Gu, L
AU  - Gu L
AD  - Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical 
      School, Boston, Massachusetts 02115, USA.
FAU - Rutledge, B
AU  - Rutledge B
FAU - Fiorillo, J
AU  - Fiorillo J
FAU - Ernst, C
AU  - Ernst C
FAU - Grewal, I
AU  - Grewal I
FAU - Flavell, R
AU  - Flavell R
FAU - Gladue, R
AU  - Gladue R
FAU - Rollins, B
AU  - Rollins B
LA  - eng
GR  - CA53091/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/biosynthesis/genetics/*physiology
MH  - Mice
MH  - Mice, Transgenic
RF  - 32
EDAT- 1997/11/19 00:00
MHDA- 1997/11/19 00:01
CRDT- 1997/11/19 00:00
PHST- 1997/11/19 00:00 [pubmed]
PHST- 1997/11/19 00:01 [medline]
PHST- 1997/11/19 00:00 [entrez]
AID - 10.1002/jlb.62.5.577 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1997 Nov;62(5):577-80. doi: 10.1002/jlb.62.5.577.