PMID- 9365832
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 20
IP  - 3
DP  - 1997 Nov
TI  - Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular 
      event and a variety of morphologic or immunologic phenotypes.
PG  - 253-9
AB  - Previous studies described the t(10;11)(p13-14;q14-21) as a recurring 
      translocation associated with T-cell acute lymphoblastic leukemia (ALL). This 
      translocation has also been reported in monocytic leukemia or ALL with a very 
      early pre-B phenotype. However, whether these cytogenetically similar 
      translocations involve the same molecular breakpoint is unknown. Using 
      fluorescence in situ hybridization (FISH) with a series of probes on 11q, we 
      mapped the 11q breakpoint of the U937 cell line, which was derived from a patient 
      with diffuse histiocytic lymphoma and was shown by FISH to have the 
      t(10;11)(p13-14;q14-21). Subsequently, we identified a yeast artificial 
      chromosome (YAC) clone, y960g8, that included the breakpoint on 11q. From this 
      YAC, we isolated a PI clone, P91B1, that was split by the 10;11 translocation. We 
      studied four patients with a t(10;11), one of whom had acute monocytic leukemia 
      (AMoL), one had acute lymphoblastic leukemia (ALL), one had lymphoblastic 
      lymphoma (LBL), and one had granulocytic sarcoma, by using FISH with y960g8 and 
      P91B1. Y960g8 and P91B1 were split by the translocation in each patient. We 
      showed that P91B1 included a recently identified gene, CALM (Clathrin Assembly 
      Lymphoid Myeloid leukemia gene), and that AF10 was also rearranged in each 
      patient by FISH when we used y807b3, which contains the AF10 gene. These findings 
      indicate that hematologic malignant diseases with fusion of AF10 and CALM show 
      various morphologic and immunologic phenotypes, suggesting that this fusion 
      occurs in multipotential or very early precursor cells.
FAU - Kobayashi, H
AU  - Kobayashi H
AD  - Third Clinical Department, Saitama Cancer Center Hospital, Japan.
FAU - Hosoda, F
AU  - Hosoda F
FAU - Maseki, N
AU  - Maseki N
FAU - Sakurai, M
AU  - Sakurai M
FAU - Imashuku, S
AU  - Imashuku S
FAU - Ohki, M
AU  - Ohki M
FAU - Kaneko, Y
AU  - Kaneko Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Adult
MH  - Child
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Female
MH  - Humans
MH  - *Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Metaphase
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/immunology
MH  - Translocation, Genetic/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1997/11/20 07:04
MHDA- 2000/06/20 09:00
CRDT- 1997/11/20 07:04
PHST- 1997/11/20 07:04 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/11/20 07:04 [entrez]
AID - 10.1002/(SICI)1098-2264(199711)20:3<253::AID-GCC5>3.0.CO;2-1 [pii]
AID - 10.1002/(sici)1098-2264(199711)20:3<253::aid-gcc5>3.0.co;2-1 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Nov;20(3):253-9. doi: 
      10.1002/(sici)1098-2264(199711)20:3<253::aid-gcc5>3.0.co;2-1.