PMID- 9365837
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20171116
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 20
IP  - 3
DP  - 1997 Nov
TI  - A case of atypical myelodysplastic syndrome with micromegakaryocytes, normal 
      platelet count, and t(3;12)(q21;p13) with inv(3)(q21q26).
PG  - 292-8
AB  - A 49-year-old woman patient with atypical myelodysplastic syndrome (MDS) showing 
      a der(3)t(3;12)(q21;p13), and der(12)t(3;12)(q21;p13)inv(3)(q21q26) as an 
      acquired chromosomal abnormality in the bone marrow is described. The chromosomal 
      breakpoints of the presented complex aberration with combination of the 
      inv(3)(q21q26) and t(3;12)(q21;p13) were defined by fluorescence in situ 
      hybridization (FISH) with yeast artificial chromosomes (YACs). The inv(3) is a 
      relatively frequent chromosomal rearrangement in patients with myeloid 
      malignancies and dysmegakaryopoiesis and t(3;12)(q26;p13) has also been reported 
      as a recurrent abnormality in MDS and in blast crisis of chronic myelogenous 
      leukemia (CML). Whereas the t(3;12), inv(3), and t(3;3) are associated with a 
      very poor prognosis, our patient surprisingly had a mild clinical course.
FAU - Schnittger, S
AU  - Schnittger S
AD  - AG Tumorcytogenetik, Institut fur Humangenetik, Medizinischen Universitat zu 
      Lubeck, Germany.
FAU - Schoch, C
AU  - Schoch C
FAU - Streubel, B
AU  - Streubel B
FAU - Hinrichs, H F
AU  - Hinrichs HF
FAU - Otremba, B
AU  - Otremba B
FAU - Parwaresch, R
AU  - Parwaresch R
FAU - Fonatsch, C
AU  - Fonatsch C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MDS1 and EVI1 Complex Locus Protein)
RN  - 0 (MECOM protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Chromosome Banding
MH  - *Chromosome Inversion
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - DNA, Neoplasm/isolation & purification
MH  - DNA-Binding Proteins/genetics
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - MDS1 and EVI1 Complex Locus Protein
MH  - Megakaryocytes/*pathology
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/blood/*genetics/pathology
MH  - Platelet Count
MH  - Polymerase Chain Reaction
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - Translocation, Genetic/*genetics
EDAT- 1997/11/20 07:04
MHDA- 2000/06/20 09:00
CRDT- 1997/11/20 07:04
PHST- 1997/11/20 07:04 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/11/20 07:04 [entrez]
AID - 10.1002/(SICI)1098-2264(199711)20:3<292::AID-GCC10>3.0.CO;2-R [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Nov;20(3):292-8.