PMID- 9365838
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20231213
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 20
IP  - 3
DP  - 1997 Nov
TI  - BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion.
PG  - 299-304
AB  - A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as 
      the sole chromosomal abnormality was investigated by fluorescence in situ 
      hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously 
      called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion 
      was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused 
      in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the 
      FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric 
      transcripts have previously been reported in acute leukemias, but never before in 
      CML. The present case suggests that ETV6/ABL positivity may constitute a new 
      genetic subgroup of BCR-negative CML.
FAU - Andreasson, P
AU  - Andreasson P
AD  - Department of Clinical Genetics, Lund University Hospital, Sweden.
FAU - Johansson, B
AU  - Johansson B
FAU - Carlsson, M
AU  - Carlsson M
FAU - Jarlsfelt, I
AU  - Jarlsfelt I
FAU - Fioretos, T
AU  - Fioretos T
FAU - Mitelman, F
AU  - Mitelman F
FAU - Hoglund, M
AU  - Hoglund M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Adult
MH  - Blotting, Southern
MH  - Bone Marrow Cells/chemistry
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - DNA, Neoplasm/isolation & purification
MH  - DNA-Binding Proteins/*genetics
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Genes, abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Polymerase Chain Reaction
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic/genetics
MH  - ETS Translocation Variant 6 Protein
EDAT- 1997/11/20 07:04
MHDA- 2000/06/20 09:00
CRDT- 1997/11/20 07:04
PHST- 1997/11/20 07:04 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/11/20 07:04 [entrez]
AID - 10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Nov;20(3):299-304.