PMID- 9366305
OWN - NLM
STAT- MEDLINE
DCOM- 19971124
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 80
IP  - 10
DP  - 1997 Nov 15
TI  - Hyperbaric oxygen therapy for radiation-induced brain injury in children.
PG  - 2005-12
AB  - BACKGROUND: Radiation-induced necrosis (RIN) of the brain is a complication 
      associated with the use of aggressive focal treatments such as radioactive 
      implants and stereotactic radiosurgery. In an attempt to treat patients with 
      central nervous system (CNS) RIN, ten patients received hyperbaric oxygen 
      treatment (HBOT). METHODS: Patients presented with new or increasing neurologic 
      deficits associated with imaging changes after radiotherapy. Necrosis was proven 
      by biopsy in eight cases. HBOT was comprised of 20-30 sessions at 2.0 to 2.4 
      atmospheres, for 90 minutes-2 hours. Sites of RIN included the brain stem (n = 
      2), posterior fossa (n = 1), and supratentorial fossa (n 7). Histologic types 
      included brain stem glioma (n = 2), ependymoma (n = 2), germinoma (n = 2), low 
      grade astrocytoma (n = 1), oligodendroglioma (n = 1), glioblastoma multiforme (n 
      = 1), and arteriovenous malformation (n = 1). RESULTS: Initial improvement or 
      stabilization of symptoms and/or imaging findings were documented in all ten 
      patients studied and no severe HBOT toxicity was observed. Four patients died, 
      with the cause of death attributed to tumor progression. Five of six surviving 
      patients were improved by clinical and imaging criteria; one patient was alive 
      with tumor present at last follow-up. CONCLUSIONS: HBOT may prove to be an 
      important adjunct to surgery and steroid therapy for CNS RIN.
FAU - Chuba, P J
AU  - Chuba PJ
AD  - Department of Radiation Oncology, Karmanos Cancer Institute, Wayne State 
      University, Detroit, Michigan 48236, USA.
FAU - Aronin, P
AU  - Aronin P
FAU - Bhambhani, K
AU  - Bhambhani K
FAU - Eichenhorn, M
AU  - Eichenhorn M
FAU - Zamarano, L
AU  - Zamarano L
FAU - Cianci, P
AU  - Cianci P
FAU - Muhlbauer, M
AU  - Muhlbauer M
FAU - Porter, A T
AU  - Porter AT
FAU - Fontanesi, J
AU  - Fontanesi J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Injuries/*etiology/pathology/*therapy
MH  - Brain Neoplasms/radiotherapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Necrosis
MH  - Radiation Injuries/*therapy
MH  - Radiotherapy/*adverse effects
EDAT- 1997/11/20 07:05
MHDA- 2000/06/20 09:00
CRDT- 1997/11/20 07:05
PHST- 1997/11/20 07:05 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/11/20 07:05 [entrez]
AID - 10.1002/(SICI)1097-0142(19971115)80:10<2005::AID-CNCR19>3.0.CO;2-0 [pii]
AID - 10.1002/(sici)1097-0142(19971115)80:10<2005::aid-cncr19>3.0.co;2-0 [doi]
PST - ppublish
SO  - Cancer. 1997 Nov 15;80(10):2005-12. doi: 
      10.1002/(sici)1097-0142(19971115)80:10<2005::aid-cncr19>3.0.co;2-0.