PMID- 9366516
OWN - NLM
STAT- MEDLINE
DCOM- 19971125
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 61
IP  - 20
DP  - 1997
TI  - Distinct effects of MK-801 and (+/-)-2-amino-5-phosphonopentanoic acid on 
      N-methyl-D-aspartate-induced rise of brain temperature in rats.
PG  - PL 289-94
AB  - Intracerebroventricular (i.c.v.) administration of N-methyl-D-aspartate (NMDA) 
      caused a biphasic rise of brain temperature, namely, a rapid, early rise and a 
      larger, late rise, in urethane-anesthetized rats. I.c.v. pretreatment with a 
      noncompetitive NMDA receptor antagonist, MK-801, attenuated the late rise of the 
      brain temperature, but had no effect on the early rise, whereas i.c.v. 
      pretreatment with a competitive NMDA receptor antagonist, 
      (+/-)-2-amino-5-phosphonopentanoic acid (AP-5), attenuated both rises. AP-5 per 
      se caused a rise in brain temperature without any rise of rectal temperature, 
      whereas MK-801 per se caused no significant change of the brain or rectal 
      temperature. This rise by AP-5 was suppressed by MK-801, suggesting an agonistic 
      effect of AP-5 on NMDA receptors in rat brain in vivo.
FAU - Hara, S
AU  - Hara S
AD  - Department of Forensic Medicine, Tokyo Medical College, Japan. 
      s-hara@tokyo-med.ac.jp
FAU - Mukai, T
AU  - Mukai T
FAU - Kuriiwa, F
AU  - Kuriiwa F
FAU - Iwata, N
AU  - Iwata N
FAU - Yanase, T
AU  - Yanase T
FAU - Kano, S
AU  - Kano S
FAU - Endo, T
AU  - Endo T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 118492-04-9 (2-amino-5-phosphono-3-pentenoic acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Brain/*drug effects
MH  - Dizocilpine Maleate/*pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Male
MH  - N-Methylaspartate/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/physiology
MH  - Rectum
EDAT- 1997/01/01 00:00
MHDA- 1997/11/20 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/11/20 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0024-3205(97)00867-9 [pii]
AID - 10.1016/s0024-3205(97)00867-9 [doi]
PST - ppublish
SO  - Life Sci. 1997;61(20):PL 289-94. doi: 10.1016/s0024-3205(97)00867-9.