PMID- 9368317
OWN - NLM
STAT- MEDLINE
DCOM- 19980115
LR  - 20081121
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 15 Suppl 2
DP  - 1997
TI  - Potential use of hematopoietic stem cells after radiation injury.
PG  - 305-10
AB  - Bone marrow transplantation has been used for several years in the treatment of 
      hematopoietic system malfunction. However, this particular therapy option has had 
      minimal benefit when the hematopoietic system failure results from radiation 
      exposure, such as that after the Chernobyl accident. In the last ten years, there 
      has been considerable progress in the development of methods to encourage stem 
      cell repopulation with the application of hematopoietic growth factors, and to 
      reconstitute the hematopoietic system with stem cells extracted from the 
      peripheral blood. Problems with allogeneic bone marrow or peripheral blood stem 
      cell transplantation as a therapy option include graft-versus-host disease and a 
      shortage of human leukocyte antigen (HLA)-matched donors. These problems can be 
      overcome if an autologous bone marrow or peripheral blood transplant is 
      performed, but this is not always practical. Another approach to combat these 
      difficulties is the use of umbilical cord blood as a source of donor cells, since 
      placental blood is rich in stem cells and less prone to lead to graft-versus-host 
      disease than mature blood.
FAU - Bishop, M R
AU  - Bishop MR
AD  - University of Nebraska Medical Center, Omaha, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Hematopoietic Cell Growth Factors)
SB  - IM
MH  - *Bone Marrow Transplantation/adverse effects
MH  - Graft vs Host Disease
MH  - Hematopoietic Cell Growth Factors/therapeutic use
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - *Power Plants
MH  - Radiation Injuries/etiology/*therapy
MH  - *Radioactive Hazard Release
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
MH  - Ukraine
RF  - 32
EDAT- 1997/01/01 00:00
MHDA- 1997/11/22 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/11/22 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/stem.5530150740 [doi]
PST - ppublish
SO  - Stem Cells. 1997;15 Suppl 2:305-10. doi: 10.1002/stem.5530150740.