PMID- 9368481
OWN - NLM
STAT- MEDLINE
DCOM- 19971204
LR  - 20190920
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 75
IP  - 3
DP  - 1997 Sep
TI  - Thrombotic events are not exclusive to the remission induction period in patients 
      with acute lymphoblastic leukemia: a report of two cases of cerebral sinus 
      thrombosis.
PG  - 117-9
AB  - It is well established that in acute lymphoblastic leukemia (ALL) patients 
      L-asparaginase (L-Ase) provokes thrombotic events reducing coagulation inhibitors 
      in both adults and children. A tight correlation between thrombotic and 
      hemorrhagic complications and ALL has also been hypothesized because of the high 
      incidence of disseminated intravascular coagulation (DIC) found during the early 
      period of chemotherapeutic treatment apart from L-Ase. All the authors reporting 
      on this subject, however, consider the remission induction phase of treatment the 
      most risky, if not exclusive, for the development of a thrombotic event, in 
      particular if it includes the administration of L-Ase. We report here two cases 
      of ALL patients who experienced a cerebral sinus thrombosis in a later phase of 
      treatment, demonstrating that the thrombotic risk is surely exacerbated by 
      chemotherapy but is not exclusive to the remission induction period.
FAU - Corso, A
AU  - Corso A
AD  - Institute of Hematology, Policlinico San Matteo, Pavia, Italy.
FAU - Castagnola, C
AU  - Castagnola C
FAU - Bernasconi, C
AU  - Bernasconi C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - EC 3.5.1.1 (Asparaginase)
SB  - IM
MH  - Adult
MH  - Asparaginase/adverse effects
MH  - Female
MH  - Humans
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*complications/*drug 
      therapy/physiopathology
MH  - Remission Induction
MH  - Sinus Thrombosis, Intracranial/chemically induced/etiology
EDAT- 1997/11/22 00:00
MHDA- 1997/11/22 00:01
CRDT- 1997/11/22 00:00
PHST- 1997/11/22 00:00 [pubmed]
PHST- 1997/11/22 00:01 [medline]
PHST- 1997/11/22 00:00 [entrez]
AID - 10.1007/s002770050324 [doi]
PST - ppublish
SO  - Ann Hematol. 1997 Sep;75(3):117-9. doi: 10.1007/s002770050324.