PMID- 9369341
OWN - NLM
STAT- MEDLINE
DCOM- 19980122
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 334
IP  - 2-3
DP  - 1997 Sep 10
TI  - Intracerebroventricular injection of isoproterenol produces its analgesic effect 
      through interleukin-1beta production.
PG  - 133-40
AB  - The effects of isoproterenol, a beta-adrenoceptor agonist, on the production of 
      interleukin-1beta in the brain and on mechanical nociception were examined in 
      rats. Intracerebroventricular (i.c.v.) injection of isoproterenol at the dose of 
      3 microg/rat markedly induced interleukin-1beta mRNA in the molecular layer of 
      the hippocampus, medial preoptic area, paraventricular thalamic nucleus, 
      paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, 
      dorsomedial hypothalamic nucleus and central gray 1 h after injection. In these 
      regions, interleukin-1beta mRNA was expressed mainly in the glial cells. The 
      thresholds to the mechanical stimulation to the hind paw were elevated by i.c.v. 
      administration of isoproterenol (1 to 10 microg/rat). When isoproterenol was 
      given at the dose of 3 microg/rat, the analgesic effect showed two peaks. The 
      first peak was observed at 60 min after injection and the second was observed at 
      180 min. The second phase of analgesia was antagonized by coadministration of 
      interleukin-1 receptor antagonist. These results suggest that isoproterenol 
      produces an analgesic effect, at least in part, through the induction of 
      interleukin-1beta expression in the brain.
FAU - Yabuuchi, K
AU  - Yabuuchi K
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, 
      Japan.
FAU - Maruta, E
AU  - Maruta E
FAU - Yamamoto, J
AU  - Yamamoto J
FAU - Nishiyori, A
AU  - Nishiyori A
FAU - Takami, S
AU  - Takami S
FAU - Minami, M
AU  - Minami M
FAU - Satoh, M
AU  - Satoh M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin-1)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Analgesics/administration & dosage/*pharmacology
MH  - Animals
MH  - Blotting, Northern
MH  - Brain/drug effects/metabolism
MH  - Histocytochemistry
MH  - In Situ Hybridization
MH  - Injections, Intraventricular
MH  - Interleukin-1/*biosynthesis/genetics
MH  - Isoproterenol/administration & dosage/*pharmacology
MH  - Male
MH  - Pain Measurement/drug effects
MH  - Physical Stimulation
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Interleukin-1/antagonists & inhibitors
EDAT- 1997/11/22 00:00
MHDA- 1997/11/22 00:01
CRDT- 1997/11/22 00:00
PHST- 1997/11/22 00:00 [pubmed]
PHST- 1997/11/22 00:01 [medline]
PHST- 1997/11/22 00:00 [entrez]
AID - S0014-2999(97)01196-5 [pii]
AID - 10.1016/s0014-2999(97)01196-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1997 Sep 10;334(2-3):133-40. doi: 10.1016/s0014-2999(97)01196-5.