PMID- 9370237
OWN - NLM
STAT- MEDLINE
DCOM- 19971210
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 56
IP  - 11
DP  - 1997 Nov
TI  - Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals 
      without AIDS.
PG  - 1262-8
AB  - The presence of neuropsychological disturbances in HIV-positive, pre-symptomatic 
      individuals is a controversial issue. Neuroimaging studies have not shown brain 
      atrophy or hyperintensity in the white matter, whereas proton magnetic resonance 
      spectroscopy has revealed some abnormality of cerebral biochemistry. Using an 
      antibody to beta-amyloid precursor protein (beta-APP), we previously demonstrated 
      frequent and widespread axonal changes in the brains of AIDS patients. In this 
      study, we extended the use of beta-APP to asymptomatic patients in order to 
      establish a possible morphological correlation with neuropsychological disorders. 
      Brain samples from 29 patients were examined. Results showed bundles of 
      beta-APP-positive axons in 8/29 cases (27%). The changes, seen in both 
      superficial and deep white matter, were either focal or diffuse, could not be 
      visualized by silver or ubiquitin stains, and did not coexist with any change in 
      distribution or morphology of astrocytes and microglial cells. We conclude that 
      in HIV-positive asymptomatic individuals, axonal changes: (a) may be related to 
      the state of immune activation with consequent presence of toxic substances, 
      including cytokines, observed in these patients; (b) may represent mild changes 
      that could undergo repair, unless other pathological events, such as the 
      supervening of the AIDS stage and the specific encephalitis, make them permanent.
FAU - An, S F
AU  - An SF
AD  - Department of Neuropathology, Institute of Neurology, London.
FAU - Giometto, B
AU  - Giometto B
FAU - Groves, M
AU  - Groves M
FAU - Miller, R F
AU  - Miller RF
FAU - Beckett, A A
AU  - Beckett AA
FAU - Gray, F
AU  - Gray F
FAU - Tavolato, B
AU  - Tavolato B
FAU - Scaravilli, F
AU  - Scaravilli F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Axons/*metabolism/*pathology
MH  - Brain/metabolism/pathology
MH  - DNA, Viral/metabolism
MH  - HIV Seropositivity/genetics/*metabolism/*pathology
MH  - HIV-1/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Polymerase Chain Reaction
MH  - Tissue Distribution
EDAT- 1997/11/25 00:00
MHDA- 1997/11/25 00:01
CRDT- 1997/11/25 00:00
PHST- 1997/11/25 00:00 [pubmed]
PHST- 1997/11/25 00:01 [medline]
PHST- 1997/11/25 00:00 [entrez]
AID - 10.1097/00005072-199711000-00011 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1997 Nov;56(11):1262-8. doi: 
      10.1097/00005072-199711000-00011.