PMID- 9371489
OWN - NLM
STAT- MEDLINE
DCOM- 19971201
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 57
IP  - 22
DP  - 1997 Nov 15
TI  - Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level 
      during breast carcinogenesis.
PG  - 4992-6
AB  - Some of the nuclear retinoic acid receptors (RARs) alpha, beta, and gamma and 
      retinoid X receptors (RXRs) alpha, beta, and gamma are thought to mediate the 
      effects of retinoids on cell growth, differentiation, and apoptosis and thereby 
      prevent breast carcinogenesis. We analyzed the expression of mRNAs for the three 
      RARs and RXR-alpha in histological sections of specimens from 70 breast cancer 
      patients, which included adjacent normal tissue, ductal carcinoma in situ, and 
      invasive cancer, using in situ hybridization. RARs alpha, beta, and gamma and 
      RXR-alpha were expressed in 98.1, 98.0, 93.0, and 100% of the adjacent normal 
      tissues. Significant decreases in the number of cases expressing RAR-beta were 
      observed among ductal carcinoma in situ (83.1%) and invasive carcinomas (51.6%), 
      especially among the poorly differentiated cases (77.4 and 35.7 %, respectively). 
      No relationship was found between the expression of estrogen receptor and 
      RAR-beta. These results implicate decreases in RAR-beta expression in breast 
      cancer development and suggest that they are independent of estrogen receptor 
      status.
FAU - Xu, X C
AU  - Xu XC
AD  - Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson 
      Cancer Center, Houston 77030, USA.
FAU - Sneige, N
AU  - Sneige N
FAU - Liu, X
AU  - Liu X
FAU - Nandagiri, R
AU  - Nandagiri R
FAU - Lee, J J
AU  - Lee JJ
FAU - Lukmanji, F
AU  - Lukmanji F
FAU - Hortobagyi, G
AU  - Hortobagyi G
FAU - Lippman, S M
AU  - Lippman SM
FAU - Dhingra, K
AU  - Dhingra K
FAU - Lotan, R
AU  - Lotan R
LA  - eng
GR  - CN-45006-32/CN/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - Breast/*metabolism
MH  - Breast Neoplasms/*metabolism
MH  - Carcinoma in Situ/*metabolism
MH  - Carcinoma, Ductal, Breast/*metabolism
MH  - Female
MH  - Humans
MH  - Neoplasm Proteins/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Receptors, Retinoic Acid/genetics/*metabolism
EDAT- 1997/11/26 00:00
MHDA- 1997/11/26 00:01
CRDT- 1997/11/26 00:00
PHST- 1997/11/26 00:00 [pubmed]
PHST- 1997/11/26 00:01 [medline]
PHST- 1997/11/26 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1997 Nov 15;57(22):4992-6.