PMID- 9372452
OWN - NLM
STAT- MEDLINE
DCOM- 19971230
LR  - 20191210
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 3
IP  - 5
DP  - 1997 Oct
TI  - The latency associated transcripts (LAT) of herpes simplex virus: still no end in 
      sight.
PG  - 313-21
AB  - The herpes simplex virus latency associated transcripts (LAT) are the only viral 
      gene products that accumulate to a high concentration in the trigeminal ganglia 
      (TG) of latently infected animals. Their abundance is particularly surprising, 
      since they are thought to be the introns of a larger, approximately 8.3 kb 
      precursor. LAT are not linear molecules. Therefore they are either a circle or a 
      lariat that is not debranched. This structure could explain their unusual high 
      stability. Moreover, the functional potential of stable, nuclear RNA has been 
      demonstrated in other biological systems and could offer a clue as to the 
      mechanism of action of LAT. Therefore, the non-linear nature of LAT and 
      functional implications mean that both literally and figuratively, there is no 
      end in sight for this unusual molecule.
FAU - Block, T M
AU  - Block TM
AD  - Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 
      19107-6799, USA.
FAU - Hill, J M
AU  - Hill JM
LA  - eng
GR  - EY06311/EY/NEI NIH HHS/United States
GR  - EY08701/EY/NEI NIH HHS/United States
GR  - NS33768/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Circular)
RN  - 0 (RNA, Viral)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - DNA, Viral/*chemistry
MH  - Humans
MH  - Nucleic Acid Conformation
MH  - RNA/chemistry
MH  - RNA, Circular
MH  - RNA, Viral/chemistry
MH  - Simplexvirus/*genetics
MH  - Transcription, Genetic
MH  - Virus Latency/*genetics
RF  - 58
EDAT- 1998/01/07 00:00
MHDA- 1998/01/07 00:01
CRDT- 1998/01/07 00:00
PHST- 1998/01/07 00:00 [pubmed]
PHST- 1998/01/07 00:01 [medline]
PHST- 1998/01/07 00:00 [entrez]
AID - 10.3109/13550289709030745 [doi]
PST - ppublish
SO  - J Neurovirol. 1997 Oct;3(5):313-21. doi: 10.3109/13550289709030745.