PMID- 9372651
OWN - NLM
STAT- MEDLINE
DCOM- 19971216
LR  - 20231213
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 156
IP  - 5
DP  - 1997 Nov
TI  - HLA class II genes in soybean epidemic asthma patients.
PG  - 1394-8
AB  - From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean 
      dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. 
      Because only a small proportion of asthmatic individuals living in Barcelona 
      expressed the epidemic phenotype, it is hypothesized that a genetically 
      determined human leukocyte antigen (HLA) Class II factor could have played a role 
      in the susceptible individuals. Accordingly, we studied the distribution of both 
      HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the 
      HLA-DR and HLA-DQ genes for genetic polymorphisms of the beta 1 chain was done 
      with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, 
      and the findings were compared with those for 67 nonepidemic asthmatic 
      individuals and 168 individuals from the general population. An allelic 
      disequilibrium could be established; the risk of epidemic asthma was particularly 
      associated with the DRB1*13 gene (p value corrected for multiple comparisons < 
      0.02). The association observed for the DRB1*13 gene was stronger in individuals 
      in the lowest tertile for total IgE, with an estimated risk with a 95% confidence 
      interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among 
      the DRB1*05-05, DRB1*05-06, and DRB1*06-06 genes was present in epidemic 
      asthmatic subjects only. No association with an HLA-DQB1 allele could be 
      observed. Genetic predisposition could contribute to the response of some 
      asthmatic patients to exposure to soybean dust, having led to their being 
      affected during the epidemics of asthma in Barcelona.
FAU - Soriano, J B
AU  - Soriano JB
AD  - Environmental and Respiratory Health Research Unit, Institut Municipal 
      d'Investigacio Medica, Barcelona, Spain.
FAU - Ercilla, G
AU  - Ercilla G
FAU - Sunyer, J
AU  - Sunyer J
FAU - Real, F X
AU  - Real FX
FAU - Lazaro, C
AU  - Lazaro C
FAU - Rodrigo, M J
AU  - Rodrigo MJ
FAU - Estivill, X
AU  - Estivill X
FAU - Roca, J
AU  - Roca J
FAU - Rodriguez-Roisin, R
AU  - Rodriguez-Roisin R
FAU - Morell, F
AU  - Morell F
FAU - Anto, J M
AU  - Anto JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Dust)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alleles
MH  - Asthma/epidemiology/etiology/*genetics/immunology
MH  - Bronchial Provocation Tests
MH  - Confidence Intervals
MH  - *Disease Outbreaks
MH  - Disease Susceptibility
MH  - Dust/*adverse effects
MH  - Female
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - *Inhalation Exposure
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Glycine max/*adverse effects
MH  - Spain/epidemiology
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - 10.1164/ajrccm.156.5.9701064 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1997 Nov;156(5):1394-8. doi: 
      10.1164/ajrccm.156.5.9701064.