PMID- 9373179
OWN - NLM
STAT- MEDLINE
DCOM- 19971208
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 416
IP  - 3
DP  - 1997 Oct 27
TI  - Characterization of two receptors for TRAIL.
PG  - 329-34
AB  - Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. 
      Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is 
      structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and 
      is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell 
      death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative 
      phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the 
      presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats 
      (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the 
      expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and 
      skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, 
      suggesting a complex regulation of TRAIL-mediated signals.
FAU - Schneider, P
AU  - Schneider P
AD  - Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
FAU - Bodmer, J L
AU  - Bodmer JL
FAU - Thome, M
AU  - Thome M
FAU - Hofmann, K
AU  - Hofmann K
FAU - Holler, N
AU  - Holler N
FAU - Tschopp, J
AU  - Tschopp J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Member 10c)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNFRSF10A protein, human)
RN  - 0 (TNFRSF10B protein, human)
RN  - 0 (TNFRSF10C protein, human)
RN  - 0 (TNFSF10 protein, human)
RN  - 0 (Tumor Necrosis Factor Decoy Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Apoptosis
MH  - Apoptosis Regulatory Proteins
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - GPI-Linked Proteins
MH  - Humans
MH  - Kinetics
MH  - Lymphocytes/metabolism
MH  - Membrane Glycoproteins/*metabolism
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/metabolism
MH  - Polymerase Chain Reaction
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand
MH  - Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Member 10c
MH  - Recombinant Proteins/biosynthesis/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sequence Tagged Sites
MH  - Signal Transduction
MH  - TNF-Related Apoptosis-Inducing Ligand
MH  - Transfection
MH  - Tumor Necrosis Factor Decoy Receptors
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - S0014-5793(97)01231-3 [pii]
AID - 10.1016/s0014-5793(97)01231-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1997 Oct 27;416(3):329-34. doi: 10.1016/s0014-5793(97)01231-3.