PMID- 9373195
OWN - NLM
STAT- MEDLINE
DCOM- 19971212
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 27
IP  - 1-2
DP  - 1997 Sep
TI  - Clinical indications of multiple integrations of human T-cell lymphotropic virus 
      type I proviral DNA in adult T-cell leukemia/lymphoma.
PG  - 43-51
AB  - In this review, we discuss the possible relationship between the clinical 
      characteristics and the multiple integration of human T-cell lymphotropic virus 
      type I (HTLV-I) proviral DNA in patients with adult T-cell leukemia/lymphoma 
      (ATL). Some patients with ATL show multiple HTLV-I integrations and exhibit 
      clinical characteristics unlike those of ATL patients who show the typical 
      integration of a single provirus. Multiple HTLV-I integrations can be detected by 
      Southern blotting as multiple bands having varied intensities. These multiple 
      integration conditions can arise from one tumor cell clone carrying multiple 
      copies of the provirus, or from multiple cell clones, each carrying one copy of 
      the provirus. The former patients manifest an extremely aggressive clinical 
      course with the infiltration of unusual organs such as the retina and uvea. The 
      latter patients show an indolent clinical course with skin lesions. These 
      findings suggest that the clinical implications for multiple HTLV-I integrations 
      exist in ATL. This may be one of the explanations for the heterogeneous findings 
      in the disease. Such observations may provide information linking viral 
      integration with clinical manifestations, and improve our understanding of the 
      pathogenesis of ATL.
FAU - Shimamoto, Y
AU  - Shimamoto Y
AD  - Department of Internal Medicine, Saga Medical School, Nabeshima, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/*genetics
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/*virology
MH  - Proviruses/*genetics
MH  - *Virus Integration
RF  - 53
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - 10.3109/10428199709068270 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1997 Sep;27(1-2):43-51. doi: 10.3109/10428199709068270.