PMID- 9374268
OWN - NLM
STAT- MEDLINE
DCOM- 19980217
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 769
IP  - 1
DP  - 1997 Sep 19
TI  - 5-HT3 receptors in the ventromedial nucleus of the hypothalamus and female sexual 
      behavior.
PG  - 13-20
AB  - Within the ventromedial nucleus of the hypothalamus (VMN), serotonin exerts a 
      dual role in the control of female rat lordosis behavior. Most emphasis has been 
      placed on 5-HT1A and 5-HT2 receptors, which inhibit and facilitate the behavior, 
      respectively. In the current experiment, a potential role for VMN 5-HT3 receptors 
      in the control of lordosis behavior was examined. Ovariectomized rats, hormonally 
      primed with 25 microg estradiol benzoate and 500 microg progesterone, received 
      bilateral VMN infusions with 100 ng, 250 ng or 500 ng of the 5-HT3 receptor 
      antagonist, tropisetron. In these rats, there was a dose-dependent decline in 
      both the lordosis to mount (L/M) ratio and in the quality of the lordosis reflex 
      with 500 ng tropisetron producing the most consistent change in lordosis 
      behavior. Relative to hormone-primed, ovariectomized rats, lordosis behavior of 
      proestrous females was less affected by VMN infusions with the 5-HT3 receptor 
      antagonist. The 5-HT3 receptor agonist, m-chlorophenylbiguanide (mCPBG), 
      attenuated the effect of tropisetron; of the three mCPBG doses (500 ng, 1000 ng, 
      1500 ng) examined, 1000 ng was the most effective, perhaps because, alone, 1500 
      ng mCPBG slightly reduced lordosis behavior. These observations emphasize the 
      potential role for VMN 5-HT3 receptors in the control of lordosis behavior.
FAU - Maswood, N
AU  - Maswood N
AD  - Department of Biology, Texas Women's University, Denton 76204, USA.
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Biguanides)
RN  - 0 (Indoles)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 6I819NIK1W (Tropisetron)
RN  - 910A4X901V (1-(3-chlorophenyl)biguanide)
SB  - IM
MH  - Animals
MH  - Biguanides/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Estradiol/pharmacology
MH  - Female
MH  - Indoles/pharmacology
MH  - Ovariectomy
MH  - Proestrus/physiology
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Serotonin/*metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - *Sex Characteristics
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Time Factors
MH  - Tropisetron
MH  - Ventromedial Hypothalamic Nucleus/*metabolism/physiology
EDAT- 1997/11/28 00:00
MHDA- 1997/11/28 00:01
CRDT- 1997/11/28 00:00
PHST- 1997/11/28 00:00 [pubmed]
PHST- 1997/11/28 00:01 [medline]
PHST- 1997/11/28 00:00 [entrez]
AID - S0006-8993(97)00670-7 [pii]
AID - 10.1016/s0006-8993(97)00670-7 [doi]
PST - ppublish
SO  - Brain Res. 1997 Sep 19;769(1):13-20. doi: 10.1016/s0006-8993(97)00670-7.