PMID- 9374291
OWN - NLM
STAT- MEDLINE
DCOM- 19980217
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 769
IP  - 1
DP  - 1997 Sep 19
TI  - Zinc distribution in the brain of Nagase analbuminemic rat and enlargement of the 
      ventricular system.
PG  - 193-5
AB  - 65ZnCl2 was intravenously injected into Nagase analbuminemic rats (NAR), which 
      have a genetical mutation affecting albumin mRNA processing and lack serum 
      albumin, to test the hypothesis that albumin is necessary for zinc (Zn) transport 
      into the brain. One hour after injection, 65Zn was largely concentrated in the 
      choroid plexus of NAR as well as normal parental Sprague-Dawley rats (SDR). Six 
      days after injection, in both groups, the 65Zn concentration in the choroid 
      plexus decreased, with increases in other brain regions. The finding that there 
      was no significant difference in brain distribution of 65Zn between NAR and SDR 
      suggests that Zn transport into the brain and its distribution through the 
      blood-cerebrospinal fluid barrier as well as the blood-brain barrier are not 
      dependent on serum albumin. A most interesting observation was that the cerebral 
      ventricles were considerably enlarged in NAR.
FAU - Takeda, A
AU  - Takeda A
AD  - Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of 
      Shizuoka, Japan. takedaa@ys7.u-shizuoka-ken.ac.jp
FAU - Kawai, M
AU  - Kawai M
FAU - Okada, S
AU  - Okada S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Serum Albumin)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Cerebral Ventricles/*pathology
MH  - Choroid Plexus/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*metabolism
MH  - Tissue Distribution
MH  - Zinc/*metabolism
EDAT- 1997/11/28 00:00
MHDA- 1997/11/28 00:01
CRDT- 1997/11/28 00:00
PHST- 1997/11/28 00:00 [pubmed]
PHST- 1997/11/28 00:01 [medline]
PHST- 1997/11/28 00:00 [entrez]
AID - S0006-8993(97)00852-4 [pii]
AID - 10.1016/s0006-8993(97)00852-4 [doi]
PST - ppublish
SO  - Brain Res. 1997 Sep 19;769(1):193-5. doi: 10.1016/s0006-8993(97)00852-4.