PMID- 9375749
OWN - NLM
STAT- MEDLINE
DCOM- 19971223
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 99
IP  - 2
DP  - 1997 Nov
TI  - mRNA expression of Fas receptor (CD95)-associated proteins (Fas-associated 
      phosphatase-1/FAP-1, Fas-associating protein with death domain/FADD, and 
      receptor-interacting protein/RIP) in human leukaemia/lymphoma cell lines.
PG  - 325-30
AB  - mRNA expression of Fas (CD95)-associated proteins [Fas-associating protein with 
      death domain (FADD), receptor-interacting protein (RIP), and Fas-associated 
      phosphatase-1 (FAP-1)] has been investigated in 26 Fas-positive human 
      leukaemia/lymphoma cell lines. Reverse transcriptase-polymerase chain reaction 
      analysis revealed that FADD and RIP mRNA were invariably expressed in both 
      Fas-sensitive and Fas-insensitive cell lines. However, FAP-1 mRNA was detected in 
      only 11 of 26 cell lines. Interestingly 7/14 cell lines in the Fas-sensitive 
      group were positive for FAP-1 mRNA expression. 8/12 cell lines in the 
      Fas-refractory group did not express FAP-1 mRNA, but half of these cell lines 
      were susceptible to tumour necrosis factor alpha-induced growth inhibition. These 
      findings suggest that the presence or absence of FAP-1 mRNA expression did not 
      always correlate with relative sensitivity of Fas-mediated growth inhibition. 
      Furthermore, it is assumed that leukaemia/lymphoma cells could possess structural 
      or functional defects of Fas or Fas-associated proteins resulting in the failure 
      to trigger apoptotic cell death.
FAU - Komada, Y
AU  - Komada Y
AD  - Department of Paediatrics, Mie University School of Medicine, Tsu, Japan.
FAU - Inaba, H
AU  - Inaba H
FAU - Zhou, Y W
AU  - Zhou YW
FAU - Zhang, X L
AU  - Zhang XL
FAU - Tanaka, S
AU  - Tanaka S
FAU - Azuma, E
AU  - Azuma E
FAU - Sakurai, M
AU  - Sakurai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (FADD protein, human)
RN  - 0 (Fas-Associated Death Domain Protein)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
RN  - EC 2.7.11.1 (RIPK1 protein, human)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Carrier Proteins/*metabolism
MH  - Cell Division
MH  - DNA Fragmentation
MH  - Fas-Associated Death Domain Protein
MH  - Flow Cytometry
MH  - Humans
MH  - Leukemia/*metabolism/pathology
MH  - Lymphoma/*metabolism/pathology
MH  - Proteins/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Receptor-Interacting Protein Serine-Threonine Kinases
MH  - Tumor Cells, Cultured
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - fas Receptor/*metabolism
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - 10.1046/j.1365-2141.1997.3903204.x [doi]
PST - ppublish
SO  - Br J Haematol. 1997 Nov;99(2):325-30. doi: 10.1046/j.1365-2141.1997.3903204.x.