PMID- 9376541
OWN - NLM
STAT- MEDLINE
DCOM- 19971107
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 8
IP  - 13
DP  - 1997 Sep 8
TI  - Dopamine D2 receptor upregulation in rat neostriatum following in vivo infusion 
      of forskolin.
PG  - 2971-6
AB  - Intracerebroventricular (i.c.v.) forskolin infusion for 5 days resulted in a 
      concentration-dependent increase in rat striatal dopamine (DA) D2 receptors 
      measured with [3H]raclopride. In animals given 50 nmol/h forskolin, the highest 
      concentration used, raclopride-mediated suppression of spontaneous locomotor 
      activity was attenuated, and (+/-)-7-hydroxy-dipropyl-aminotetralin HBr 
      (7-OH-DPAT)-mediated inhibition of striatal DA synthesis, as estimated by the 
      accumulation of DOPA following inhibition of cerebral decarboxylase, was 
      enhanced. These data suggest that the DA D2 receptor increase comprises receptors 
      localized both post- and presynaptically. The density of striatal DA D1 receptors 
      was also changed with the forskolin treatment, in a concentration-dependent 
      fashion, but in the opposite direction to DA D2 receptors. These findings suggest 
      that striatal DA receptor sensitivity can be changed by manipulation at the 
      second messenger level (e.g. independent of direct neurotransmitter-receptor 
      interactions) in vivo.
FAU - Wanderoy, M H
AU  - Wanderoy MH
AD  - CNS Preclinical R&D, Astra Arcus AB, Sodertalje, Sweden.
FAU - Westlind-Danielsson, A
AU  - Westlind-Danielsson A
FAU - Ahlenius, S
AU  - Ahlenius S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Salicylamides)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 1F7A44V6OU (Colforsin)
RN  - 430K3SOZ7G (Raclopride)
RN  - RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles
MH  - Colforsin/*pharmacology
MH  - Dopamine Agonists/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - In Vitro Techniques
MH  - Infusions, Parenteral
MH  - Male
MH  - Neostriatum/*drug effects/metabolism
MH  - Raclopride
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Dopamine D2/*drug effects/metabolism
MH  - Salicylamides/pharmacology
MH  - Tetrahydronaphthalenes/pharmacology
MH  - Up-Regulation
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
AID - 10.1097/00001756-199709080-00033 [doi]
PST - ppublish
SO  - Neuroreport. 1997 Sep 8;8(13):2971-6. doi: 10.1097/00001756-199709080-00033.