PMID- 9376667
OWN - NLM
STAT- MEDLINE
DCOM- 19971112
LR  - 20191102
IS  - 0950-3536 (Print)
IS  - 0950-3536 (Linking)
VI  - 10
IP  - 2
DP  - 1997 Jun
TI  - Allografting for chronic myeloid leukaemia.
PG  - 319-36
AB  - Marrow transplantation from human leukocyte antigen (HLA) matched related donors 
      offers a high probability of prolonged treatment-free survival for patients with 
      chronic myeloid leukaemia in chronic phase. Delay, patient and donor gender, 
      patient age and previous palliation with busulphan predict outcome in this 
      setting. Because of the median age at diagnosis and the genetics of the HLA 
      system, transplants from HLA-matched related donors are available to less than 
      15% of newly diagnosed patients. Alternative donors include relatives with minor 
      degrees of incompatibility and HLA-compatible unrelated volunteers. The 
      probability of finding suitable unrelated donors has increased with the 
      development of a network of registries now containing more than 3.6 million 
      donors worldwide. Survival prospects will be improved by transplantation earlier 
      in the course of the disease, better-matched donors and the discovery of new 
      approaches for the prevention of graft-versus-host disease and opportunistic 
      infections.
FAU - Clift, R A
AU  - Clift RA
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 
      98104, USA.
FAU - Anasetti, C
AU  - Anasetti C
LA  - eng
GR  - AI 33484/AI/NIAID NIH HHS/United States
GR  - CA 18029/CA/NCI NIH HHS/United States
GR  - HL 36444/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Baillieres Clin Haematol
JT  - Bailliere's clinical haematology
JID - 8800474
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
MH  - Male
MH  - Tissue Donors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
RF  - 66
EDAT- 1997/06/01 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1016/s0950-3536(97)80010-8 [doi]
PST - ppublish
SO  - Baillieres Clin Haematol. 1997 Jun;10(2):319-36. doi: 
      10.1016/s0950-3536(97)80010-8.