PMID- 937803
OWN - NLM
STAT- MEDLINE
DCOM- 19760901
LR  - 20061115
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 37
IP  - 7
DP  - 1976 Jul
TI  - Clinical, serologic, and pathologic changes in calves with experimentally induced 
      Trypanosoma brucei infection.
PG  - 791-802
AB  - In 7 calves inoculated with Trypanosoma brucei and observed for 105 days, the 
      minimal clinical signs were occasional lethargic periods associated with 
      parasitemia. Rectal temperatures increased by postinoculation day (pid), 10, 
      remained moderately high until PID 50 to 60, and then returned to base line. 
      Moderate anemia occurred between PID 15 and 25. Slightly increased lymphocyte 
      count with relative decrease in neutrophil count was found in 3 calves. 
      Monocytosis of minimal degree occurred 14 days after parasitemia. Trypanosome 
      counts of low level and irregular frequency were found throughout the infection. 
      The average number of trypanosomes in blood was approximately 1,000/ml. Antibody 
      titers, as determined by the indirect immunofluorescent antibody method, appeared 
      on PID 22 and stayed at moderate levels. The immunoglobulin M first increased at 
      PID 5 and remained high (av 216% of base line value) throughout infection, but 
      immunoglobulin G was never increased. Histopathologic study revealed 
      proliferative changes in the lymph nodes and spleen characteristic of humoral 
      antibody (B-cell) response. Mononuclear cell infiltration (lymphocytes and plasma 
      cells), eosinophols, and edema were common in the lymph nodes, spleen, liver, 
      heart, brain, hypophysis, testes, kidney, skeletal muscle, adrenal gland, 
      pancreas, and uterus.
FAU - Moulton, J E
AU  - Moulton JE
FAU - Sollod, A E
AU  - Sollod AE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Anemia/veterinary
MH  - Animals
MH  - Brain/pathology
MH  - Cattle
MH  - Female
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Liver/pathology
MH  - Lung/pathology
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Myocardium/pathology
MH  - Spleen/pathology
MH  - Testis/pathology
MH  - *Trypanosomiasis, Bovine/immunology/pathology
EDAT- 1976/07/01 00:00
MHDA- 1976/07/01 00:01
CRDT- 1976/07/01 00:00
PHST- 1976/07/01 00:00 [pubmed]
PHST- 1976/07/01 00:01 [medline]
PHST- 1976/07/01 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1976 Jul;37(7):791-802.