PMID- 9379076
OWN - NLM
STAT- MEDLINE
DCOM- 19971112
LR  - 20230315
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 16
IP  - 3
DP  - 1997
TI  - Selection of the MHC class II-associated peptide repertoire by HLA-DM.
PG  - 261-72
AB  - During the past five years considerable progress has been made in the field of 
      major histocompatibility complex (MHC) class II-restricted antigen presentation. 
      Several observations made in mutant cell lines with a presentation defect led to 
      the identification of a novel protein, the nonclassic MHC class II molecule human 
      leukocyte antigen (HLA)-DM. Cell biological and biochemical characterization of 
      HLA-DM provided deeper insight into the molecular mechanism underlying the 
      loading process: HLA-DM accumulates in acidic compartments where it binds to 
      classic class II molecules as long as no high-stability ligand occupies the 
      peptide-binding groove. Thus, HLA-DM prevents empty alpha beta dimers from 
      functional inactivation in a chaperone-like fashion. At the same time HLA-DM acts 
      as an editor by removing low-stability ligands, thereby skewing the class II 
      peptide repertoire presentable to T-helper cells.
FAU - Arndt, S O
AU  - Arndt SO
AD  - Department of Molecular Immunology, German Cancer Research Center, Heildelberg, 
      Germany.
FAU - Vogt, A B
AU  - Vogt AB
FAU - Hammerling, G J
AU  - Hammerling GJ
FAU - Kropshofer, H
AU  - Kropshofer H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (H2-M antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DM antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Ligands)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - HLA-D Antigens/*immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Ligands
MH  - Peptide Mapping
RF  - 75
EDAT- 1997/01/01 00:00
MHDA- 1997/10/10 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/10/10 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1007/BF02786394 [doi]
PST - ppublish
SO  - Immunol Res. 1997;16(3):261-72. doi: 10.1007/BF02786394.