PMID- 9384290
OWN - NLM
STAT- MEDLINE
DCOM- 19980107
LR  - 20210526
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 4
IP  - 6
DP  - 1997 Nov
TI  - Enzyme-linked immunosorbent assay for detection of antibody to human herpesvirus 
      6.
PG  - 687-91
AB  - The results obtained with an enzyme-linked immunosorbent assay (ELISA) for 
      detection of human herpesvirus 6 (HHV-6) immunoglobulin G using a single 1:100 
      dilution of serum correlated well with those found by an indirect fluorescence 
      microscopic assay (IFA) (r = 0.71). Concordant results were found in all 7 paired 
      serum samples obtained from patients with acute primary infections and in 37 of 
      41 (90.24%) single serum samples. Fourteen serum samples (25%) which yielded 
      nonspecific results by IFA were evaluable by ELISA. In a serologic survey using 
      the ELISA, a disproportionate number of 12-month-old infants had low 
      difference-of-optical-density values, suggesting that maternal antibody might 
      persist beyond a year of age. This finding and the rises in antibody to HHV-6 
      found in patients with primary cytomegalovirus infections might lead to 
      overestimation of HHV-6 infection rates in young children in seroprevalence 
      studies. Other herpesvirus infections produced lesser effects on anti-HHV-6.
FAU - Chokephaibulkit, K
AU  - Chokephaibulkit K
AD  - Ahmanson Pediatric Center, Cedars-Sinai Medical Center, Los Angeles, California 
      90048, USA.
FAU - Brunell, P A
AU  - Brunell PA
FAU - Vimal, V
AU  - Vimal V
FAU - Long, C
AU  - Long C
FAU - Schnabel, K
AU  - Schnabel K
FAU - Hall, C B
AU  - Hall CB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Herpesviridae Infections/blood/immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Infant
MH  - Microscopy, Fluorescence
PMC - PMC170641
EDAT- 1998/01/10 00:00
MHDA- 1998/01/10 00:01
PMCR- 1997/11/01
CRDT- 1998/01/10 00:00
PHST- 1998/01/10 00:00 [pubmed]
PHST- 1998/01/10 00:01 [medline]
PHST- 1998/01/10 00:00 [entrez]
PHST- 1997/11/01 00:00 [pmc-release]
AID - 10.1128/cdli.4.6.687-691.1997 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 1997 Nov;4(6):687-91. doi: 10.1128/cdli.4.6.687-691.1997.