PMID- 9384537
OWN - NLM
STAT- MEDLINE
DCOM- 19980205
LR  - 20190920
IS  - 0959-4388 (Print)
IS  - 0959-4388 (Linking)
VI  - 7
IP  - 5
DP  - 1997 Oct
TI  - Cell biology of polysialic acid.
PG  - 640-6
AB  - The unusual carbohydrate polysialic acid (PSA), attached uniquely to neural cell 
      adhesion molecule (NCAM) through a developmentally regulated process, modulates 
      neural cell interactions. Major advances in the past two years have increased our 
      understanding of PSA biosynthesis and regulation. Of particular interest is the 
      cloning of the genes encoding polysialyltransferases (PSTs) and the finding that 
      a single enzyme is able to confer polysialylation to NCAM. The electrical 
      activity of neurons and transmembrane signalling are probably major players in 
      controlling both PSA biosynthesis and its expression at the cell surface. A 
      direct causal relationship between PSA expression and activity-induced synaptic 
      plasticity has been reported.
FAU - Kiss, J Z
AU  - Kiss JZ
AD  - Department of Morphology, University of Geneva Medical School, Geneva, 
      Switzerland. Kiss@medecine.unige.ch
FAU - Rougon, G
AU  - Rougon G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Neurobiol
JT  - Current opinion in neurobiology
JID - 9111376
RN  - 0 (Polysaccharides)
RN  - 0 (Sialic Acids)
RN  - 0 (polysialic acid)
SB  - IM
MH  - Animals
MH  - *Cell Physiological Phenomena
MH  - Humans
MH  - Polysaccharides/biosynthesis/*physiology
MH  - Sialic Acids/biosynthesis/*physiology
RF  - 64
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - S0959-4388(97)80083-9 [pii]
AID - 10.1016/s0959-4388(97)80083-9 [doi]
PST - ppublish
SO  - Curr Opin Neurobiol. 1997 Oct;7(5):640-6. doi: 10.1016/s0959-4388(97)80083-9.