PMID- 9385379
OWN - NLM
STAT- MEDLINE
DCOM- 19971224
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 101
IP  - 1
DP  - 1997 Nov
TI  - Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 
      (MEN1) region.
PG  - 102-8
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in 
      which affected individuals develop tumors primarily in the parathyroids, anterior 
      pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked 
      to the marker PYGM on chromosome 11q13, and linkage analysis has previously 
      placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and 
      D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have 
      helped narrow the location of the gene to a 600-kb interval between PYGM and 
      D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers 
      were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 
      interval. These new markers, along with 14 previously known polymorphic markers, 
      were precisely mapped on a 2.8-Mb (D11S480-D11S913) high-density clone 
      contig-based, physical map generated for the MEN1 region.
FAU - Manickam, P
AU  - Manickam P
AD  - Laboratory of Gene Transfer, National Human Genome Research Institute, National 
      Institutes of Health, Bethesda, MD 20892-4442, USA.
FAU - Guru, S C
AU  - Guru SC
FAU - Debelenko, L V
AU  - Debelenko LV
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Weisemann, J M
AU  - Weisemann JM
FAU - Boguski, M S
AU  - Boguski MS
FAU - Crabtree, J S
AU  - Crabtree JS
FAU - Wang, Y
AU  - Wang Y
FAU - Roe, B A
AU  - Roe BA
FAU - Lubensky, I A
AU  - Lubensky IA
FAU - Zhuang, Z
AU  - Zhuang Z
FAU - Kester, M B
AU  - Kester MB
FAU - Burns, A L
AU  - Burns AL
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Marx, S J
AU  - Marx SJ
FAU - Liotta, L A
AU  - Liotta LA
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Collins, F S
AU  - Collins FS
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
LA  - eng
SI  - GENBANK/G31868
SI  - GENBANK/G31869
SI  - GENBANK/G31870
SI  - GENBANK/G31871
SI  - GENBANK/G31872
SI  - GENBANK/G31873
SI  - GENBANK/G31890
SI  - GENBANK/G31891
SI  - GENBANK/G31892
SI  - GENBANK/G31893
SI  - GENBANK/G31894
SI  - GENBANK/G31895
SI  - GENBANK/G31896
SI  - GENBANK/G31897
SI  - GENBANK/G31898
SI  - GENBANK/G31899
GR  - HG00313/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (DNA Primers)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Alleles
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Cosmids
MH  - DNA Primers/genetics
MH  - Dinucleotide Repeats
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Minisatellite Repeats
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Sequence Tagged Sites
EDAT- 1998/01/07 00:00
MHDA- 1998/01/07 00:01
CRDT- 1998/01/07 00:00
PHST- 1998/01/07 00:00 [pubmed]
PHST- 1998/01/07 00:01 [medline]
PHST- 1998/01/07 00:00 [entrez]
AID - 10.1007/s004390050595 [doi]
PST - ppublish
SO  - Hum Genet. 1997 Nov;101(1):102-8. doi: 10.1007/s004390050595.