PMID- 9386984
OWN - NLM
STAT- MEDLINE
DCOM- 19980102
LR  - 20181201
IS  - 0304-324X (Print)
IS  - 0304-324X (Linking)
VI  - 43
IP  - 6
DP  - 1997
TI  - Factors involved in the anaemia of chronic disorders in elderly patients.
PG  - 326-34
AB  - Erythropoietin secretion was evaluated in the anaemia of chronic disorders in 
      elderly patients, since it has been shown that this secretion is impaired in 
      adults. We looked for a possible role of inflammatory cytokines: tumor necrosis 
      factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on erythropoietin 
      production. The influence of nutritional status on the anaemia was also 
      investigated. Erythropoietin secretion was significantly increased in elderly 
      patients with anaemia of chronic disorders (ACD) and inversely correlated with 
      haemoglobin concentrations in infectious and inflammatory diseases. Plasma TNF 
      alpha levels were significantly enhanced only in cancerous patients, but no 
      correlation could be established between TNF alpha and erythropoietin or 
      haemoglobin. No noticeable increase of IL-1 beta levels was observed in ACD. 
      These findings suggest that systemic TNF alpha or IL-1 beta are not involved in 
      the erythropoietin response to ACD. Albumin levels were decreased in anaemic 
      patients. Further investigations of the effects of a nutritional supplementation 
      in elderly patients with ACD may be of interest.
FAU - Pieroni, L
AU  - Pieroni L
AD  - Laboratoire d'Hematologie Cellulaire et Moleculaire, Universite Rene Descartes, 
      Paris, France.
FAU - Foglietti, M J
AU  - Foglietti MJ
FAU - Andreux, J P
AU  - Andreux JP
FAU - Albou, D
AU  - Albou D
FAU - Nafziger, J
AU  - Nafziger J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
RN  - 0 (Hemoglobins)
RN  - 0 (Interleukin-1)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Anemia/*physiopathology
MH  - Chronic Disease
MH  - Erythropoietin/blood/metabolism
MH  - Female
MH  - Hemoglobins
MH  - Humans
MH  - Interleukin-1/blood
MH  - Male
MH  - Serum Albumin
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1997/01/01 00:00
MHDA- 1997/12/05 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/12/05 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000213872 [doi]
PST - ppublish
SO  - Gerontology. 1997;43(6):326-34. doi: 10.1159/000213872.