PMID- 9387397
OWN - NLM
STAT- MEDLINE
DCOM- 19971231
LR  - 20161020
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 11
IP  - 3
DP  - 1996 Sep
TI  - Retinoic acid nuclear receptor alpha(RAR alpha) plays a major role in 
      retinoid-mediated inhibition of growth in human breast carcinoma cells.
PG  - 142-6
AB  - Retinoids mediate their actions via retinoic acid receptors (RARs) and retinoid X 
      receptors (RXRs). Each of class of these nuclear retinoid receptor is further 
      subdivided into three species namely alpha, beta and gamma. Recently studies 
      demonstrated that estrogen receptor (ER)-positive human breast cancer (HBC) cell 
      lines are sensitive and ER-negative cell lines are resistant to growth inhibitory 
      effects of retinoic acid (RA). In this study, we found that only RAR alpha mRNA 
      levels was strongly correlated with ER-status. To further investigate the major 
      role of RAR alpha in retinoid-mediated inhibition of growth, we transfected RAR 
      alpha cDNA into two RA-resistant ER-negative HBC cell lines. Analysis of 
      different clonal populations of RAR alpha transfectants from each cell line 
      revealed growth inhibition by retinoids. Our results demonstrated that RAR alpha 
      plays a major role in mediating retinoids inhibition of growth in HBC cells and 
      adequate levels of RAR alpha are required for such an effect.
FAU - Shao, Z
AU  - Shao Z
AD  - Department of Surgery, Cancer Hospital, Shanghai Medical University.
FAU - Yu, L
AU  - Yu L
FAU - Shen, Z
AU  - Shen Z
FAU - Fontana, J A
AU  - Fontana JA
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Breast Neoplasms/*metabolism/pathology
MH  - Cell Division/drug effects
MH  - Humans
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, Retinoic Acid/genetics/metabolism/*physiology
MH  - Retinoid X Receptors
MH  - Transcription Factors/genetics/metabolism
MH  - Transfection
MH  - Tretinoin/*pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1996/09/01 00:00
MHDA- 1997/12/05 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1997/12/05 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PST - ppublish
SO  - Chin Med Sci J. 1996 Sep;11(3):142-6.