PMID- 9387466 OWN - NLM STAT- MEDLINE DCOM- 19980109 LR - 20161020 IS - 1000-7806 (Print) IS - 1000-7806 (Linking) VI - 12 IP - 4 DP - 1996 Jul TI - [DNA contents and cycle analysis of porcine burn wounds treated with growth factors]. PG - 262-4 AB - Wound healing is a complex biologic process in which peptide growth factors play a very important role. The object of this research was to study the effects of recombinant human epidermal growth factors (rh-EGF) and acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF) and bovine brain extract (bBE) on porcine partial-thickness burn wound healing. The biopsies were taken for determination of DNA contents and cell DNA cycle with the aid of flow cytometry and histological observation. The results showed that more extensive reepithelization and greater thickness of epidermis exhibited in growth factor treated wounds, and DNA contents and percent of S phase of cell DNA cycle were also higher in those groups treated with growth factors. The results suggested that repeated topical application of rh-EGF, aFGF, bFGF and bBE accelerated epithelial healing of burn wounds, and it may be helpful in clinical practice. FAU - Pan, Y AU - Pan Y AD - Burn Center, Changhai Hospital, Second Military Medical University, Shanghai. FAU - Dai, F AU - Dai F FAU - Chen, Y AU - Chen Y LA - chi PT - English Abstract PT - Journal Article PL - China TA - Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi JT - Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns JID - 8510296 RN - 0 (Recombinant Proteins) RN - 0 (Tissue Extracts) RN - 103107-01-3 (Fibroblast Growth Factor 2) RN - 104781-85-3 (Fibroblast Growth Factor 1) RN - 62229-50-9 (Epidermal Growth Factor) RN - 9007-49-2 (DNA) SB - IM MH - Animals MH - Burns/metabolism/*therapy MH - DNA/*analysis MH - Epidermal Growth Factor/*therapeutic use MH - Fibroblast Growth Factor 1/therapeutic use MH - Fibroblast Growth Factor 2/therapeutic use MH - Recombinant Proteins/therapeutic use MH - Swine MH - Tissue Extracts/therapeutic use MH - Wound Healing/drug effects EDAT- 1996/07/01 00:00 MHDA- 1997/12/05 00:01 CRDT- 1996/07/01 00:00 PHST- 1996/07/01 00:00 [pubmed] PHST- 1997/12/05 00:01 [medline] PHST- 1996/07/01 00:00 [entrez] PST - ppublish SO - Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1996 Jul;12(4):262-4.