PMID- 9387719
OWN - NLM
STAT- MEDLINE
DCOM- 19971216
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 16
IP  - 5
DP  - 1996 May
TI  - [Effect of new zhengtian pill on 5-hydroxytryptamine content in platelet and 
      plasma of migraine patients].
PG  - 280-2
AB  - Changes of 5-hydroxytryptamine (5-HT) content in platelet and plasma before and 
      after New Zhengtian Pill (NZTP) therapy in migraine patients were assayed with 
      fluorospectrophotometry. Results showed that during the period of attack, the 
      platelet 5-HT level of patients in comparing with normal control group, was 
      increased (P < 0.05) but the plasma 5-HT level decreased (P < 0.01) and the ratio 
      of the platelet and plasma 5-HT was abnormal P < 0.01. While during the 
      intermittent period the 5-HT was increased both in platelet and plasma and the 
      ratio of intra- and extra-platelet 5-HT was normal. Also, in comparing with 
      before treatment, the post-treatmental plasma levels of 5-HT in patients with or 
      without acute attack were all increased, the above-mentioned 5-HT ratio was also 
      resumed obviously (P < 0.05). This study revealed that both the plasma 5-HT and 
      platelet 5-HT levels and their ratio of patients in acute attack period were 
      abnormal, which might be the pathogenetic basis of migraine. It suggested the 
      mechanism of NZTP in treating migraine might be through its action on absorption, 
      releasing and metabolism of 5-HT by platelet and maintaining a physiologic 
      balance in them.
FAU - Wang, D N
AU  - Wang DN
AD  - 252 Hospital of PLA, Baoding.
FAU - Chen, B T
AU  - Chen BT
FAU - Zhou, Y L
AU  - Zhou YL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Platelets/*chemistry
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*blood/drug therapy
MH  - Serotonin/*blood
EDAT- 1996/05/01 00:00
MHDA- 1997/12/05 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1997/12/05 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 May;16(5):280-2.